INT292607

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
interneurons 2
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 6 100.00 Very High Very High Very High
GABAergic 18 99.84 Very High Very High Very High
Transcranial magnetic stimulation 36 75.92 Quite High
cannabis 52 51.20 Quite High
cerebral cortex 1 10.92 Low Low
Cannabinoid 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
Delta-9-tetrahydrocannabinol 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 106 98.92 Very High Very High Very High
Disease 7 72.68 Quite High
Drug Dependence 43 59.04 Quite High
Cannabis Dependence 24 48.64 Quite Low
Syndrome 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Handedness 2 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Psychosis 2 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In schizophrenia, GABAergic dysfunction, decreased levels of the mRNA expression of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67), and a reduction of GABAergic interneurons are all observed (Benes 1998; Knable et al. 2002; Lewis et al. 2005).
Negative_regulation (reduction) of Transcription (expression) of GAD67 in interneurons associated with gaba, gabaergic and schizophrenia
1) Confidence 0.02 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.72 Pain Relevance 0.36

General Comments

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