INT292703

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 50.00 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
qutenza 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 179 99.90 Very High Very High Very High
Stress 67 91.48 High High
Chronic Myeloid Leukemia 32 90.96 High High
Myeloid Leukemia 48 86.40 High High
Apoptosis 34 78.96 Quite High
Congenital Anomalies 4 73.52 Quite High
Cancer 20 65.56 Quite High
Philadelphia Chromosome 8 62.12 Quite High
Genetic Translocation 4 59.52 Quite High
Blast Crisis 4 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From this dataset, genes which fell into three groups were identified including 1) HSF1-dependent regulation by HS, 2) HSF1-independent regulation by HS and 3) altered regulation between wild-type and HSF1-null MEFs in the absence of HS.
Neg (independent) Regulation (regulation) of HSF1 associated with shock
1) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.56 Pain Relevance 0
However the role of upstream kinases in controlling HSF1 activity was not properly delved into.
Regulation (controlling) of HSF1
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.43 Pain Relevance 0
activation and upregulation of ERK1/2 activity by Resveratrol in modulating the transcriptional efficacy of HSF1 and subsequent lowering of the Hsp70 levels in K562 cells.


Regulation (efficacy) of HSF1
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
However how Resveratrol modulates HSF1 activity remains unexplored.
Regulation (modulates) of HSF1
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.62 Pain Relevance 0
Since Resveratrol blocked Akt activation it was essential to demonstrate if Akt activation pathway was involved in modulating the subcellular distribution and activation of HSF1, the transcription factor responsible for expression of hsp70 gene.
Regulation (modulating) of HSF1
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.17 Pain Relevance 0

General Comments

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