INT292704

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
nucleus 2
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 80.04 Quite High
Apoptosis 16 67.52 Quite High
Myeloid Leukemia 24 50.00 Quite Low
Chronic Myeloid Leukemia 16 50.00 Quite Low
Shock 14 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Philadelphia Chromosome 4 5.00 Very Low Very Low Very Low
Blast Crisis 2 5.00 Very Low Very Low Very Low
Alkalosis 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measuring the levels of cytosolic and nuclear fraction of HSF1 by Western blot analysis, it was found that exposure to 0.5µM Wortmanin for 24h appreciably augmented the cytosolic localization of HSF1 which showed a further increase at 1µM concentration.
Positive_regulation (augmented) of Localization (localization) of HSF1
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.15 Pain Relevance 0
in presence of Resveratrol definitely contributes to the blocking of HSF1 translocation to the nucleus and hence Hsp70 expression.
Positive_regulation (hence) of Localization (translocation) of HSF1 in nucleus
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0

General Comments

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