INT292714

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.34
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 120 100.00 Very High Very High Very High
Central nervous system 14 82.64 Quite High
agonist 2 73.92 Quite High
Inflammation 34 39.04 Quite Low
Eae 2 37.76 Quite Low
Hippocampus 10 24.32 Low Low
cytokine 27 21.84 Low Low
Pyramidal cell 2 6.68 Low Low
Inflammatory response 6 5.64 Low Low
Opioid 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 101 97.80 Very High Very High Very High
Infection 62 97.76 Very High Very High Very High
Targeted Disruption 44 95.88 Very High Very High Very High
Aging 9 89.76 High High
Amyloid Plaque 8 84.40 Quite High
Congenital Anomalies 7 70.56 Quite High
Apoptosis 88 69.60 Quite High
Toxicity 2 57.32 Quite High
Stress 19 56.48 Quite High
Death 10 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these phosphorylation is contributed by GSK3?
Negative_regulation (One) of Gene_expression (contributed) of GSK
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 3B, morphine and H37Ra significantly decreased the levels of GSK3?
Negative_regulation (decreased) of Gene_expression (levels) of GSK associated with morphine
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.58 Pain Relevance 0.67
activity, these data demonstrate that morphine and H37Ra decrease GSK3?
Negative_regulation (decrease) of Gene_expression (morphine) of GSK associated with morphine
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.69 Pain Relevance 0.61
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Negative_regulation (Impaired) of Gene_expression (levels) of GSK
4) Confidence 0.41 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.07 Pain Relevance 0.04

General Comments

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