INT292723

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Hsf1) nucleus (Akt1, Hsf1) transport (Akt1)
aging (Akt1) DNA binding (Hsf1) enzyme binding (Akt1)
Akt1 (Mus musculus)
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 12 75.00 Quite High
Chronic Myeloid Leukemia 8 75.00 Quite High
Shock 7 52.92 Quite High
Apoptosis 8 52.20 Quite High
Stress 11 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Philadelphia Chromosome 2 5.00 Very Low Very Low Very Low
Blast Crisis 1 5.00 Very Low Very Low Very Low
Alkalosis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, increase in ERK1/2 activity by Resveratrol provided another negative influence on Hsp70 levels through negative regulation of HSF1 activity. 17-allylamino-17-demethoxygeldanamycin (17AAG), a drug that inhibits Hsp90 chaperone and degrades its client protein Akt concomitantly elevated Hsp70 levels by promoting nuclear translocation of HSF1 from the cytosol.
Akt Positive_regulation (promoting) of Localization (translocation) of HSF1
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.36 Pain Relevance 0

General Comments

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