INT29279

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd1a, Htr1a) signal transducer activity (Drd1a, Htr1a) endoplasmic reticulum (Drd1a)
nucleus (Drd1a) intracellular (Drd1a)
Drd1a (Rattus norvegicus)
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Antinociceptive 3 99.12 Very High Very High Very High
Morphine 2 95.20 Very High Very High Very High
narcan 2 78.48 Quite High
tolerance 1 75.60 Quite High
antinociception 1 75.00 Quite High
addiction 1 68.56 Quite High
Physical dependence 1 60.40 Quite High
depression 1 50.40 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 92.00 High High
Drug Dependence 1 60.40 Quite High
Respiratory Failure 1 51.36 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we describe the potent antinociceptive action of the indolophenanthridine, CY 208-243, which has high affinities to the dopamine D1 binding and the opioid sites as well as to the 5-HT1A site.
dopamine D1 Binding (binding) of 5-HT1A associated with dopamine, opioid and antinociceptive
1) Confidence 0.35 Published 1988 Journal Life Sci. Section Abstract Doc Link 2826954 Disease Relevance 0.20 Pain Relevance 0.84

General Comments

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