INT292795

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.86
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
retina 2
endothelial cells 1
brain 1
glandular epithelial cells 1
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 15 94.16 High High
endometriosis 207 81.24 Quite High
metalloproteinase 9 50.00 Quite Low
cytokine 18 18.80 Low Low
imagery 45 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
pain pelvic 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 169 99.50 Very High Very High Very High
Diabetes Mellitus 110 97.72 Very High Very High Very High
Papilledema 2 95.84 Very High Very High Very High
Endometriosis 297 95.64 Very High Very High Very High
Diabetic Macular Edema 42 83.68 Quite High
Injury 4 79.44 Quite High
Fibromyalgia 4 67.64 Quite High
Glioma 29 64.88 Quite High
Frailty 2 17.80 Low Low
Disease 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The histologic scores (H) for VEGF and Flk-1 were calculated using the formula H = ?
Regulation (calculated) of Flk-1
1) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0 Pain Relevance 0
The immunoreactivity of VEGF and Flk-1 was similar and detected focally in the cytoplasm of endothelial cells, glandular epithelial cells and diffusely in stromal cells, in both eutopic and ectopic endometrial tissues (Fig. 4).
Regulation (immunoreactivity) of Flk-1 in glandular epithelial cells
2) Confidence 0.24 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.62 Pain Relevance 0.19
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Neg (not) Regulation (alter) of FLK-1 in retina
3) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.67 Pain Relevance 0.05
Intravitreal injection of TA stabilizes the BRB in association with regulation of Vegf-a, Flk-1, and Flt-1 expression in retinas in the early stages of diabetes.



Regulation (regulation) of Flk-1 in retinas associated with diabetes mellitus
4) Confidence 0.24 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.61 Pain Relevance 0
It is to note that PTK787 treated tumors showed lower normalized values of VEGFR2 and EGFR both at the periphery and central parts of the tumors compared to that of corresponding contralateral brain; whereas vehicle treated tumors did not show any changes in the normalized values of VEGFR2 and EGFR compared to that of corresponding contralateral brain.


Regulation (values) of VEGFR2 in brain associated with cancer
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 1.33 Pain Relevance 0
The immunoreactivity of VEGF and Flk-1 was similar and detected focally in the cytoplasm of endothelial cells, glandular epithelial cells and diffusely in stromal cells, in both eutopic and ectopic endometrial tissues (Fig. 4).
Regulation (immunoreactivity) of Flk-1 in endothelial cells
6) Confidence 0.08 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.62 Pain Relevance 0.19

General Comments

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