INT292814

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.63
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Kdr) extracellular space (VEGFA) extracellular region (VEGFA)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) nucleus (Kdr)
Anatomy Link Frequency
endothelial cells 2
retinas 1
VEGFA (Homo sapiens)
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 207 90.04 High High
Potency 2 82.08 Quite High
cytokine 20 66.96 Quite High
metalloproteinase 10 62.48 Quite High
imagery 96 27.92 Quite Low
corticosteroid 16 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 354 98.52 Very High Very High Very High
Endometriosis 297 98.48 Very High Very High Very High
Diabetes Mellitus 110 97.88 Very High Very High Very High
Ganglion Cysts 4 95.44 Very High Very High Very High
Glioma 58 61.52 Quite High
Edema 6 59.16 Quite High
Diabetic Macular Edema 42 50.64 Quite High
Metastasis 2 50.52 Quite High
Prolactinoma 1 50.00 Quite Low
Pituitary Cancer 8 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF binds to either of two tyrosine kinase receptors, the fm5-like tyrosine kinase (flt) and the kinase domain receptor (KDR or Flk-1) [14].
VEGF Binding (binds) of kinase domain receptor
1) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.31 Pain Relevance 0.11
VEGF binds to either of two tyrosine kinase receptors, the fm5-like tyrosine kinase (flt) and the kinase domain receptor (KDR or Flk-1) [14].
VEGF Binding (binds) of Flk-1
2) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.31 Pain Relevance 0.11
VEGF binds to either of two tyrosine kinase receptors, the fm5-like tyrosine kinase (flt) and the kinase domain receptor (KDR or Flk-1) [14].
VEGF Binding (binds) of KDR
3) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 0.31 Pain Relevance 0.11
Flk-1 (known as VEGF receptor-2) has been shown to be expressed in endothelial cells and also is found to mediate the function of mitogenesis on VEGF stimulation [53].
VEGF Binding (receptor) of Flk-1 in endothelial cells
4) Confidence 0.11 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.58 Pain Relevance 0
Furthermore, VEGF-A mutants that bind selectively to FLK-1 are able to induce mitogenesis and chemotaxis in endothelial cells, and vascular permeability and angiogenesis in vivo, whereas VEGF-A mutants that selectively bind to FLT-1 do not have the activities stated above (29,30).
VEGF Binding (bind) of FLK-1 in endothelial cells
5) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.56 Pain Relevance 0
In nondiabetic retinas, immunoreactivity against VEGF and FLK-1 was weak in these layers in contrast to that in the diabetic retinas.
VEGF Binding (immunoreactivity) of FLK-1 in retinas associated with diabetes mellitus
6) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.60 Pain Relevance 0
However, the interaction of VEGF/VPF with Flk-1/VEGFR2 is thought to be more important for tumor angiogenesis because it is essential for induction of the full spectrum of VEGF/VPF functions [12].
VEGF Binding (interaction) of VEGFR2 associated with cancer
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.48 Pain Relevance 0.07
However, the interaction of VEGF/VPF with Flk-1/VEGFR2 is thought to be more important for tumor angiogenesis because it is essential for induction of the full spectrum of VEGF/VPF functions [12].
VEGF Binding (interaction) of Flk-1 associated with cancer
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.48 Pain Relevance 0.07

General Comments

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