INT292837

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Context Info
Confidence 0.71
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.73
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fabp1) cytosol (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
liver 4
fat 1
Caco-2 1
Fabp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 63 84.56 Quite High
fibrosis 183 72.28 Quite High
Inflammation 95 5.00 Very Low Very Low Very Low
alcohol 25 5.00 Very Low Very Low Very Low
Bile 25 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 76 99.16 Very High Very High Very High
Body Weight 10 92.96 High High
Disorder Of Lipid Metabolism 73 91.92 High High
Metabolic Syndrome 116 90.08 High High
Repression 10 86.64 High High
Fatty Liver 315 80.92 Quite High
Atherosclerotic Plaque 4 79.64 Quite High
Atherosclerosis 22 77.08 Quite High
Hyperlipidemia 41 74.72 Quite High
Cardiovascular Disease 12 72.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to wild-type mice on a high-fat(HF) diet, Clock-/- mice on the same diet showed less triglyceride accumulation in the liver by suppressing expression of Acsl4 and Fabp1 genes involved in lipid metabolism [14].
Gene_expression (expression) of Fabp1 in liver
1) Confidence 0.71 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.82 Pain Relevance 0
In the liver, expression of cyp4a10, cyp4a14 and fatty acid binding protein 1 (FABP1) was induced by 0.04% vaticanol C in the wild-type, but not in the knockout mice (Figure 3A).
Gene_expression (expression) of FABP1 in liver associated with targeted disruption
2) Confidence 0.57 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.38 Pain Relevance 0.08
In the liver, expression of cyp4a10, cyp4a14 and fatty acid binding protein 1 (FABP1) was induced by 0.04% vaticanol C in the wild-type, but not in the knockout mice (Figure 3A).
Gene_expression (expression) of fatty acid binding protein 1 in liver associated with targeted disruption
3) Confidence 0.57 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.38 Pain Relevance 0.08
CuZn superoxide dismutase (Sod1) deficient mice showed a marked decrease in MUP11 and MUP8 expression, but in this case FABP1 was also down-regulated [62].
Gene_expression (was) of FABP1
4) Confidence 0.50 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0 Pain Relevance 0
There are nine different FABPs each of which shows distinct tissue specific distribution with L-FABP being prominently expressed in the liver.
Gene_expression (expressed) of L-FABP in liver
5) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.31 Pain Relevance 0
A high fat diet potently increases the expression of L-FABP [42] and microsomal triglyceride transfer protein (MTP) via PPAR?
Gene_expression (expression) of L-FABP in fat
6) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.29 Pain Relevance 0
/L-FABP and HNF4?
Gene_expression (/) of L-FABP
7) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0 Pain Relevance 0
CD36/FAT is closely correlated with the degree of mitochondrial fatty acid oxidation, while L-FABP, also known as the mitochondrial aspartate aminotransferase (mAST), may have distinct functions at different subcellular sites.
Gene_expression (aspartate aminotransferase) of L-FABP
8) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.05 Pain Relevance 0
Thus, in hepatic steatosis, the ratio of saturated to unsaturated fatty acids with increased expression of selective fatty acid transport proteins (FATP/L-FABP/ACBP) may mediate metabolic defects accounting for hepatic steatosis.
Gene_expression (expression) of L-FABP
9) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.08 Pain Relevance 0
Conversely, the protein expression of L-FABP that participates mainly in intracellular FA trafficking was increased by almost 2-fold in CFTR knockdown cells (Figure 6B).


Gene_expression (expression) of L-FABP
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
When incubated with [14C]-oleic acid, CFTR-depleted cells were capable of quick incorporation and export to the medium concomitantly with the high protein expression of L-FABP known to promote intracellular FA trafficking.
Gene_expression (expression) of L-FABP
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864762 Disease Relevance 0.21 Pain Relevance 0.03
However, apart from increasing its buffer capacity through upregulation of L-FABP expression, Caco-2/15 cells appear to challenge the FA overload by efficiently channeling FAs toward the lipoprotein secretory pathways, i.e. the endoplasmic reticulum.
Gene_expression (expression) of L-FABP in Caco-2
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
These findings are further substantiated by the enhanced L-FABP expression and a trend toward increased expression of the FA membrane transporter, FAT/CD36.
Gene_expression (expression) of L-FABP
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.07 Pain Relevance 0.04

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