INT292873

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 15.74
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas, Fasl) extracellular region (Fas, Fasl) plasma membrane (Fas, Fasl)
cytoplasm (Fas) extracellular space (Fasl) nucleus (Fas)
Anatomy Link Frequency
Mouse 2
epithelial cells 2
hearts 2
T cells 1
Fas (Mus musculus)
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 54 99.00 Very High Very High Very High
Demyelination 4 75.28 Quite High
Inflammation 74 69.20 Quite High
alcohol 28 56.32 Quite High
Inflammatory response 12 55.24 Quite High
Central nervous system 2 37.76 Quite Low
Spinal cord 162 12.40 Low Low
ischemia 10 5.00 Very Low Very Low Very Low
peptic ulcer disease 10 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 100 99.40 Very High Very High Very High
Lymphatic System Cancer 612 99.12 Very High Very High Very High
Apoptosis 522 99.08 Very High Very High Very High
Spinal Cord Injury 244 97.16 Very High Very High Very High
Injury 70 97.12 Very High Very High Very High
Necrosis 18 97.00 Very High Very High Very High
Cancer 76 96.64 Very High Very High Very High
Infection 110 86.80 High High
Thymoma 6 82.96 Quite High
Autoimmune Disease 28 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, Fas, Fas ligand (FasL), Caspase-8 and pro-caspase-8 was examined in wild-type FVB and ADH hearts following acute ethanol challenge.
Fas Spec (examined) Binding (ligand) of FasL in hearts
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.23 Pain Relevance 0.03
, Fas, Fas ligand (FasL), Caspase-8 and pro-caspase-8 was examined in wild-type FVB and ADH hearts following acute ethanol challenge.
Fas Spec (examined) Binding (ligand) of FasL in hearts
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.22 Pain Relevance 0.03
Other studies, however, have shown that Fas/Fas-L interaction is involved in bacterial Sag mediated apoptosis [36], [42]–[43].
Fas Binding (interaction) of Fas-L associated with apoptosis
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.18 Pain Relevance 0
Mouse Fas-Fc- a competitive inhibitor of Fas-Fas-L interactions effectively inhibited apoptosis in the lymphomas studied confirming the involvement of the Fas-Fas-L pathway in apoptosis induced by bacterial Sags.
Fas-Fc Binding (interactions) of Fas-L in Mouse associated with lymphatic system cancer and apoptosis
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.13 Pain Relevance 0
Other studies, however, have shown that Fas/Fas-L interaction is involved in bacterial Sag mediated apoptosis [36], [42]–[43].
Fas Binding (interaction) of Fas-L associated with apoptosis
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.18 Pain Relevance 0
Mouse Fas-Fc- a competitive inhibitor of Fas-Fas-L interactions effectively inhibited apoptosis in the lymphomas studied confirming the involvement of the Fas-Fas-L pathway in apoptosis induced by bacterial Sags.
Fas Binding (interactions) of Fas-L in Mouse associated with lymphatic system cancer and apoptosis
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.11 Pain Relevance 0
Apoptosis of lymphoma T cells induced by bacterial Sags involves Fas-Fas-L interaction
Fas Binding (interaction) of Fas-L in T cells associated with lymphatic system cancer and apoptosis
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.82 Pain Relevance 0
Finally, mouse Fas-Fc protein was used as a competitive inhibitor of Fas/Fas-L interactions [36].
Fas-Fc Binding (interactions) of Fas-L
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.72 Pain Relevance 0
Strategies to inhibit Fas–FasL interaction may be useful neuroprotective approaches for reducing apoptosis after SCI.
Fas Binding (interaction) of FasL associated with spinal cord injury and apoptosis
9) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.33 Pain Relevance 0.10
Strategies to inhibit Fas–FasL interaction may be useful neuroprotective approaches for reducing apoptosis after SCI.
Fas Binding (interaction) of FasL associated with spinal cord injury and apoptosis
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.33 Pain Relevance 0.10
[77] and Fas/FasL interactions contribute to death of gastric epithelial cells [78].
Fas Binding (interactions) of FasL in epithelial cells associated with death
11) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.75 Pain Relevance 0.12
[77] and Fas/FasL interactions contribute to death of gastric epithelial cells [78].
Fas Binding (interactions) of FasL in epithelial cells associated with death
12) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 0.75 Pain Relevance 0.12

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