INT29290

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2009
Negated 6
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.46
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 4
pituitary 4
thyroid 2
follicle 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
anesthesia 12 100.00 Very High Very High Very High
ketamine 6 100.00 Very High Very High Very High
Buprenorphine 6 99.98 Very High Very High Very High
Dopamine 149 99.80 Very High Very High Very High
tolerance 5 99.64 Very High Very High Very High
Pain threshold 3 99.40 Very High Very High Very High
narcan 10 98.22 Very High Very High Very High
ischemia 5 98.12 Very High Very High Very High
Neurotransmitter 13 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 16 99.40 Very High Very High Very High
Stress 41 98.92 Very High Very High Very High
Cancer 8 98.36 Very High Very High Very High
Cv Unclassified Under Development 5 98.12 Very High Very High Very High
Endometriosis (extended) 5 97.82 Very High Very High Very High
Vomiting 9 96.52 Very High Very High Very High
Systemic Lupus Erythematosus 102 96.24 Very High Very High Very High
Polycystic Ovary Syndrome 50 94.76 High High
Hypertension 12 88.96 High High
Disease 29 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.
Regulation (regulating) of Gene_expression (levels) of prolactin
1) Confidence 0.49 Published 1988 Journal Clin. Sci. Section Abstract Doc Link 2827940 Disease Relevance 0 Pain Relevance 0.24
The effect on prolactin levels of the classical antypsichotic chlorpromazine, used in clinical practice for its anti-nausea properties, has been discussed above.


Regulation (effect) of Gene_expression (levels) of prolactin associated with vomiting
2) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.55 Pain Relevance 0.12
Gjonnaess in his study of long term follow up showed no difference between baseline PRL levels and PRL levels after 3 months or later after LOD [30].
Neg (no) Regulation (difference) of Gene_expression (levels) of PRL
3) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.56 Pain Relevance 0.20
Gjonnaess in his study of long term follow up showed no difference between baseline PRL levels and PRL levels after 3 months or later after LOD [30].
Neg (no) Regulation (difference) of Gene_expression (levels) of PRL
4) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.56 Pain Relevance 0.20
Immune cells produce PRL under normal circumstances regulated by a tissue-specific mechanism, different from that controlling pituitary PRL synthesis [13].
Regulation (controlling) of Gene_expression (synthesis) of PRL in pituitary
5) Confidence 0.44 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 1.01 Pain Relevance 0.33
Neither ACTH nor prolactin level in the plasma was related to the dental pain threshold elevation during ischemia.
Neg (Neither) Regulation (related) of Gene_expression (level) of prolactin in plasma associated with pain threshold and ischemia
6) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6293648 Disease Relevance 1.09 Pain Relevance 1.17
The prolactin level was unchanged at baseline before the seventh r-hPRL injection (16.9 ± 1.5 ?
Neg (unchanged) Regulation (unchanged) of Gene_expression (level) of prolactin
7) Confidence 0.42 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.18 Pain Relevance 0
In surgically or naturally menopausal women receiving different kinds of hormone replacement therapies, over 2 years and 6 months, no significant differences in serum prolactin levels were found during subsequent treatment cycles, serum prolactin showing varying levels always within normal range (Foth and Romer 1997).
Neg (no) Regulation (differences) of Gene_expression (levels) of serum prolactin associated with endometriosis (extended)
8) Confidence 0.39 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.31 Pain Relevance 0
Tolerance to buprenorphine effects on LH and prolactin levels did not occur during chronic drug administration.
Regulation (effects) of Gene_expression (levels) of prolactin associated with tolerance and buprenorphine
9) Confidence 0.38 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.09
[Measurement of serum prolactin and the effect of ketamine anesthesia on serum prolactin levels in cynomolgus monkeys (Macaca fascicularis)].
Regulation (effect) of Gene_expression (levels) of serum prolactin associated with anesthesia and ketamine
10) Confidence 0.32 Published 1985 Journal Jikken Dobutsu Section Title Doc Link 4018149 Disease Relevance 0 Pain Relevance 0.35
Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer.
Regulation (Effects) of Gene_expression (levels) of prolactin in plasma associated with pain, dopamine and cancer
11) Confidence 0.27 Published 1981 Journal Pathol. Biol. Section Title Doc Link 6262702 Disease Relevance 0.37 Pain Relevance 0.79
Immune cells produce PRL under normal circumstances regulated by a tissue-specific mechanism, different from that controlling pituitary PRL synthesis [13].
Regulation (regulated) of Gene_expression (produce) of PRL in pituitary
12) Confidence 0.23 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 0.93 Pain Relevance 0.35
A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect on plasma or serum levels of prolactin, follicle stimulating hormone, luteinizing hormone, norepinephrine or epinephrine.
Neg (no) Regulation (effect) of Gene_expression (levels) of prolactin in follicle associated with narcan
13) Confidence 0.22 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3930990 Disease Relevance 0 Pain Relevance 0.29
Production and release of prolactin, growth hormone, insulin, glucagon, thyroid hormone and gonadotrophin can be affected by physical and emotional stress (27).
Regulation (affected) of Gene_expression (Production) of prolactin in thyroid associated with stress
14) Confidence 0.20 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375238 Disease Relevance 0.91 Pain Relevance 0.09

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