INT292921

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Mns1) nucleus (Mns1)
Anatomy Link Frequency
synapse 1
Mns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 45 98.48 Very High Very High Very High
addiction 5 93.08 High High
Glutamate 40 87.68 High High
Action potential 10 66.32 Quite High
opiate 80 64.96 Quite High
gABA 5 64.56 Quite High
opioid receptor 75 44.72 Quite Low
antagonist 10 27.04 Quite Low
Opioid 75 18.40 Low Low
depression 130 17.12 Low Low
Disease Link Frequency Relevance Heat
Depression 115 17.12 Low Low
Respiratory Failure 15 5.00 Very Low Very Low Very Low
Sleep Disorders 10 5.00 Very Low Very Low Very Low
Apnoea 10 5.00 Very Low Very Low Very Low
Central Sleep Apnea 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of drug on inspiratory synaptic currents in XII MNs was also examined.
Spec (examined) Regulation (effect) of MNs
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.18
The effect of CX717 on mini EPSCs in XII inspiratory MNs was also examined in the presence of TTX (1 µM), bicuculline (10 µM), strychnine (10 µM) and DAMGO (500 nM).
Spec (examined) Regulation (effect) of MNs associated with tetrodotoxin
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.35
We also examined the effect of CX717 on AMPA receptor currents in XII MNs.
Spec (examined) Regulation (effect) of MNs
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.37
Given that DAMGO had no noticeable effect on the membrane properties of XII MNs, we next assessed whether the DAMGO-evoked reduction in inspiratory burst amplitude reflected an action on glutamatergic synaptic transmission at the pre-motor to XII MN synapse.
Neg (no) Regulation (effect) of MNs in synapse
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.14
To further investigate the mechanism underlying the CX614-mediated enhancement of inspiratory burst activity, we examined the effect of CX614 on mini EPSCs in XII inspiratory MNs.
Spec (examined) Regulation (effect) of MNs
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0 Pain Relevance 0.32

General Comments

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