INT292945

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.42
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
neurons 2
astrocytes 2
SNc 2
nervous system 2
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 46 99.68 Very High Very High Very High
Dopamine 24 98.96 Very High Very High Very High
Spinal cord 96 96.40 Very High Very High Very High
Central nervous system 45 94.92 High High
Inflammation 23 92.56 High High
Inflammatory response 8 85.84 High High
Dorsal horn 3 43.76 Quite Low
medulla 15 30.48 Quite Low
ketamine 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 36 100.00 Very High Very High Very High
Targeted Disruption 52 98.12 Very High Very High Very High
Urological Neuroanatomy 72 96.40 Very High Very High Very High
Disease 179 94.64 High High
INFLAMMATION 31 92.56 High High
Parkinson's Disease 26 60.72 Quite High
Toxicity 16 59.68 Quite High
Death 12 51.16 Quite High
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Hypokinesia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the DMV, 1.5 and 3 months rotenone treatment resulted in increased intracellular alpha-synuclein accumulation inside ChAT+ neurons (Figure 3B) when compared to controls (Figure 3A).
Positive_regulation (increased) of Positive_regulation (accumulation) of alpha-synuclein in neurons
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.51 Pain Relevance 0.23
In the SN, we observed an increase in intracellular alpha-synuclein (Figure 4B) together with larger alpha-synuclein accumulations in the substantia nigra pars compacta (SNc) (Figure 4c) similarly to that within DMV and IML.
Positive_regulation (accumulations) of Positive_regulation (increase) of alpha-synuclein in SNc associated with substantia nigra and spinal cord
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.27 Pain Relevance 0.22
Our results show that low doses of chronically and intragastrically administered rotenone induce alpha-synuclein accumulation in all the above-mentioned nervous system structures of wild-type mice.
Positive_regulation (induce) of Positive_regulation (accumulation) of alpha-synuclein in nervous system
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808242 Disease Relevance 0.64 Pain Relevance 0.20
Recently published work in the PDGFb-SNCA transgenic line [52] has demonstrated that SNCA is transmitted to astrocytes from neurons, and that the accumulation of SNCA in astrocytes leads to an increased microglial response.
Positive_regulation (leads) of Positive_regulation (accumulation) of SNCA in astrocytes associated with targeted disruption
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.51 Pain Relevance 0.14
Levels of SNCA protein have been found to increase upon exposure to oxidative stress [50], potentially through stabilization of SNCA by oxidative ligation to dopamine [19].
Positive_regulation (increase) of Positive_regulation (stabilization) of SNCA associated with stress and dopamine
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.48 Pain Relevance 0.26

General Comments

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