INT292946

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 32 72.60 Quite High
monoamine 1 55.92 Quite High
Dopamine 15 44.20 Quite Low
Catecholamine 2 41.36 Quite Low
medulla 5 18.84 Low Low
Central nervous system 18 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 129 92.40 High High
Gliosis 1 76.40 Quite High
Urological Neuroanatomy 24 72.60 Quite High
Toxicity 7 72.32 Quite High
Drug Induced Neurotoxicity 2 67.48 Quite High
Death 18 29.68 Quite Low
Stress 21 28.76 Quite Low
Parkinson's Disease 55 25.12 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether alpha-synuclein was aggregated, we double stained with alpha-synuclein and Thioflavine-S, a marker for ?
Spec (whether) Positive_regulation (whether) of Localization (aggregated) of alpha-synuclein
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.22 Pain Relevance 0.04
Additionally, we proved that an increase in free/polymerized tubulin ratio may increase alpha-synuclein oligomerization when a mitochondrial dependent ATP depletion and reactive oxygen species (ROS) generation occurs (Esteves et al., 2009).
Spec (may) Positive_regulation (increase) of Localization (oligomerization) of alpha-synuclein
2) Confidence 0.27 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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