INT292952

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 1
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 180 99.68 Very High Very High Very High
Hyperphagia 4 97.90 Very High Very High Very High
Body Weight 20 91.80 High High
Obesity 44 91.12 High High
Targeted Disruption 4 43.52 Quite Low
Appetite Loss 4 26.64 Quite Low
Cytomegalovirus Infection 4 25.60 Quite Low
Apoptosis 4 19.08 Low Low
Viral Infection 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings demonstrate that reduction in Fto expression selectively in the ARC results in increased food intake, a finding consistent with the hyperphagia seen in mice lacking Fto and congruent with the fact that fasting (a strong stimulus to eating) reduces Fto mRNA levels in the ARC [16].
Transcription (levels) of Fto associated with hyperphagia and aids-related complex
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
Fasting reduces levels of Fto mRNA in the arcuate nucleus (ARC) of the hypothalamus, a site where Fto expression is particularly high.
Transcription (levels) of Fto in hypothalamus associated with aids-related complex
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.54 Pain Relevance 0
These physiological changes was accompanied by an increase in the Fto mRNA levels in the ARC by 2.5 fold compared to rats provided with regular chow (Fig 1A).
Transcription (levels) of Fto associated with aids-related complex
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.86 Pain Relevance 0
Six pairs of oligos of 19 nucleotides within the Fto coding region of the rat were designed using Ambion software and the efficacy of these sequences in knocking down the Fto transcript was tested in cultured GT1-7 cells.
Transcription (transcript) of Fto
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0 Pain Relevance 0

General Comments

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