INT292954

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 1
fat 1
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 180 99.28 Very High Very High Very High
Obesity 44 75.00 Quite High
Body Weight 20 46.68 Quite Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Viral Infection 4 5.00 Very Low Very Low Very Low
Hyperphagia 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low
Appetite Loss 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To modulate Fto expression levels in the ARC and PVN, we generated four AAV 2/7vectors: i.)
Regulation (modulate) of Fto associated with aids-related complex
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.49 Pain Relevance 0
Here we report that a high fat diet results in an increase of ARC Fto expression, demonstrating that Fto levels can be bi-directionally regulated depending on nutritional status.
Regulation (regulated) of Fto in fat associated with aids-related complex
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.51 Pain Relevance 0
AAV mediated transfer of full length Fto cDNA was used for overexpression; ii.) shRNA targeting Fto mRNA for knockdown of gene expression and iii.) two different AAV-controls (empty vector for AAV-Fto and containing a scrambled shRNA sequence for AAV-shRNA).
Regulation (targeting) of Fto
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.40 Pain Relevance 0
Importantly, this provide the first indication that selective alteration of FTO levels in the hypothalamus can influence food intake, a finding consistent with the reported effects of FTO alleles on appetite and food intake in man.



Regulation (alteration) of FTO in hypothalamus
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.34 Pain Relevance 0

General Comments

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