INT292958

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 1
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 180 99.40 Very High Very High Very High
Targeted Disruption 4 99.36 Very High Very High Very High
Cytomegalovirus Infection 4 92.36 High High
Obesity 44 61.80 Quite High
Body Weight 20 25.40 Quite Low
Viral Infection 4 15.20 Low Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Hyperphagia 4 5.00 Very Low Very Low Very Low
Appetite Loss 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AAV mediated transfer of full length Fto cDNA was used for overexpression; ii.) shRNA targeting Fto mRNA for knockdown of gene expression and iii.) two different AAV-controls (empty vector for AAV-Fto and containing a scrambled shRNA sequence for AAV-shRNA).
Positive_regulation (targeting) of Fto
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.40 Pain Relevance 0
We have previously shown that murine Fto mRNA levels are decreased by fasting and increased by feeding in the arcuate nucleus (ARC) of the hypothalamus [16].
Positive_regulation (fasting a) of Fto in hypothalamus associated with aids-related complex
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.38 Pain Relevance 0
For the over expression studies, at the protein level, we achieved approximately 2.5 fold increase in total Fto levels in the ARC and a 1.5 fold increase in the PVN.
Positive_regulation (increase) of Fto associated with aids-related complex
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.55 Pain Relevance 0
To generate Fto expressing AAV vectors, the cDNA of murine Fto was cloned into an AAV backbone plasmid under the control of the ubiquitous hybrid promoter CAG that contains the chicken ß-actin promoter and CMV enhancer.
Positive_regulation (generate) of Fto associated with cytomegalovirus infection
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.19 Pain Relevance 0

General Comments

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