INT292962

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 9.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
neuronal 6
fat 4
hypothalamus 2
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 13 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 585 100.00 Very High Very High Very High
Apoptosis 13 97.04 Very High Very High Very High
Appetite Loss 13 96.60 Very High Very High Very High
Hyperphagia 13 94.48 High High
Obesity 143 87.84 High High
Body Weight 65 77.68 Quite High
Targeted Disruption 13 5.00 Very Low Very Low Very Low
Viral Infection 13 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 13 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the over expression studies, at the protein level, we achieved approximately 2.5 fold increase in total Fto levels in the ARC and a 1.5 fold increase in the PVN.
Positive_regulation (increase) of Gene_expression (levels) of Fto associated with aids-related complex
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.55 Pain Relevance 0
The increase in Stat3 expression associated with overexpression of Fto and reduced food intake is consistent with its potential role in mediating leptin's anorectic effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Fto associated with appetite loss
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.68 Pain Relevance 0
In this study, we have extended this nutritional link by demonstrating that consumption of a high fat diet (45%) results in a 2.5 fold increase in Arc Fto expression.
Positive_regulation (increase) of Gene_expression (expression) of Fto in fat associated with aids-related complex
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.64 Pain Relevance 0
We confirmed abundant expression of Fto in the ARC, and although its expression overlaps with that of Pomc (Fig 1B), Fto appears to be diffusely expressed throughout the ARC and is therefore likely to be present in many neuronal and non-neuronal populations.
Positive_regulation (abundant) of Gene_expression (expression) of Fto in neuronal associated with aids-related complex
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 1.00 Pain Relevance 0
Thus, rather than manipulating Fto expression in specific ARC neuronal populations, we chose a strategy employing AAV mediated transfer of Fto cDNA and shRNA coupled with stereotactic injection in order to manipulate Fto expression within the ARC (Fig 1C).


Positive_regulation (manipulating) of Gene_expression (expression) of Fto in neuronal associated with aids-related complex
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.94 Pain Relevance 0
We have further explored the role of hypothalamic Fto in the control of food intake by using stereotactic injections coupled with AAV technology to bi-directionally modulate Fto expression.
Positive_regulation (modulate) of Gene_expression (expression) of Fto
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.66 Pain Relevance 0
At the end of the experiment, we check for Fto expression as an indication for correct site of injection.
Positive_regulation (check) of Gene_expression (expression) of Fto
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.58 Pain Relevance 0
Thus, rather than manipulating Fto expression in specific ARC neuronal populations, we chose a strategy employing AAV mediated transfer of Fto cDNA and shRNA coupled with stereotactic injection in order to manipulate Fto expression within the ARC (Fig 1C).


Positive_regulation (transfer) of Gene_expression (transfer) of Fto in neuronal associated with aids-related complex
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
However, over expression of Fto resulted in a 4-fold increase in the mRNA levels of Stat3, suggesting a possible candidate for the mediation of Fto's actions within the ARC.
Positive_regulation (resulted) of Gene_expression (expression) of Fto associated with aids-related complex
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
Fasting reduces levels of Fto mRNA in the arcuate nucleus (ARC) of the hypothalamus, a site where Fto expression is particularly high.
Positive_regulation (high) of Gene_expression (expression) of Fto in hypothalamus associated with aids-related complex
10) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.61 Pain Relevance 0
Over-expression of Fto in either ARC or PVN caused a reciprocal reduction in food intake.
Positive_regulation (expression) of Gene_expression (expression) of Fto associated with aids-related complex
11) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
Over-expression of Fto in either ARC or PVN caused a reciprocal reduction in food intake.
Positive_regulation (Over) of Gene_expression (expression) of Fto associated with aids-related complex
12) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
Here we report that a high fat diet results in an increase of ARC Fto expression, demonstrating that Fto levels can be bi-directionally regulated depending on nutritional status.
Positive_regulation (increase) of Gene_expression (expression) of Fto in fat associated with aids-related complex
13) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox