INT292963

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 5.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 2
fat 2
nucleus 2
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 450 99.40 Very High Very High Very High
Obesity 110 95.92 Very High Very High Very High
Body Weight 50 93.76 High High
Hyperphagia 10 70.64 Quite High
Appetite Loss 10 68.76 Quite High
Apoptosis 10 62.96 Quite High
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Viral Infection 10 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the specificity of AAV delivery, at the end of the study, 3 weeks after AAV injections, micro-punches from both the ARC or PVN were obtained for all experimental animal and tested for changes in Fto expression using real-time quantitative RT-PCR (Fig 2B).
Regulation (changes) of Gene_expression (expression) of Fto associated with aids-related complex
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.45 Pain Relevance 0
Importantly they provide the first indication that selective alteration of Fto levels in the hypothalamus can influence food intake, a finding consistent with the reported effects of FTO alleles on appetite and food intake in man.


Regulation (alteration) of Gene_expression (levels) of Fto in hypothalamus
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.20 Pain Relevance 0
The rat Fto specific shRNA that we generated effectively inhibited the expression of endogenous Fto in hypothalamic GT1-7 cells by 90%, whereas transfection with scrambled control did not affect the production of the Fto protein (Fig 2A).
Neg (not) Regulation (affect) of Gene_expression (production) of Fto
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.35 Pain Relevance 0
mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Regulation (manipulation) of Gene_expression (expression) of Fto associated with aids-related complex
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.77 Pain Relevance 0
We have further explored the role of hypothalamic Fto in the control of food intake by using stereotactic injections coupled with AAV technology to bi-directionally modulate Fto expression.
Regulation (modulate) of Gene_expression (expression) of Fto
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.66 Pain Relevance 0
To modulate Fto expression levels in the ARC and PVN, we generated four AAV 2/7vectors: i.)
Regulation (modulate) of Gene_expression (expression) of Fto associated with aids-related complex
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.49 Pain Relevance 0
Using real-time quantitative RT-PCR we determined that the ARC-expressed genes classically associated with the control of food intake, namely, Agrp, NPY and Pomc were not affected by altered Fto expression (Fig 5).
Regulation (altered) of Gene_expression (expression) of Fto associated with aids-related complex
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.47 Pain Relevance 0
In parallel, we examined the effects of manipulating Fto levels in the nearby paraventricular nucleus (PVN), a site known to be important for the control of energy balance but where Fto expression was not altered by nutritional state [16].
Neg (not) Regulation (altered) of Gene_expression (expression) of Fto in nucleus
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.54 Pain Relevance 0
As yet, there is no evidence that the risk alleles influence FTO expression and the variants could conceivably influence adiposity through effects on more distant genes.
Regulation (influence) of Gene_expression (expression) of FTO
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.42 Pain Relevance 0
We examined the effect of high fat feeding on the expression of Fto in hypothalamic nuclei.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Fto in fat
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.78 Pain Relevance 0

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