INT292966

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fto) molecular_function (Fto) cellular_component (Fto)
Anatomy Link Frequency
hypothalamus 2
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 315 99.68 Very High Very High Very High
Hyperphagia 7 98.06 Very High Very High Very High
Obesity 77 95.52 Very High Very High Very High
Body Weight 35 85.76 High High
Apoptosis 7 10.48 Low Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Viral Infection 7 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 7 5.00 Very Low Very Low Very Low
Appetite Loss 7 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressing the data as average daily food intake, the peak of the effect was reached within the first week: 14% reduction in the Fto over expressing group and 16% increase in food intake with knockdown (Fig 3E).
Negative_regulation (reduction) of Fto
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.45 Pain Relevance 0
Fasting reduces levels of Fto mRNA in the arcuate nucleus (ARC) of the hypothalamus, a site where Fto expression is particularly high.
Negative_regulation (reduces) of Fto in hypothalamus associated with aids-related complex
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.54 Pain Relevance 0
Our findings demonstrate that reduction in Fto expression selectively in the ARC results in increased food intake, a finding consistent with the hyperphagia seen in mice lacking Fto and congruent with the fact that fasting (a strong stimulus to eating) reduces Fto mRNA levels in the ARC [16].
Negative_regulation (reduces) of Fto associated with hyperphagia and aids-related complex
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.81 Pain Relevance 0
We have previously shown that murine Fto mRNA levels are decreased by fasting and increased by feeding in the arcuate nucleus (ARC) of the hypothalamus [16].
Negative_regulation ( levels a) of Fto in hypothalamus associated with aids-related complex
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.37 Pain Relevance 0
To modulate Fto expression levels in the ARC and PVN, we generated four AAV 2/7vectors: i.)
Negative_regulation (levels) of Fto associated with aids-related complex
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.48 Pain Relevance 0
Lack of FTO from conception, in both humans [17] and mice [14], results in severe growth retardation and high levels of early mortality, accompanied in humans, but not mice, by multiple developmental anomalies.
Negative_regulation (Lack) of FTO
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.52 Pain Relevance 0
Despite this, the effects of global reduction in Fto function on energy homeostasis in mice are complex with Fto null and hypomorphic mice having low adipose stores with increased energy expenditure.
Negative_regulation (reduction) of Fto
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox