INT292971

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) nucleus (Fto) plasma membrane (Arc)
molecular_function (Fto) cytoskeleton organization (Arc) cellular_component (Fto)
Anatomy Link Frequency
neuronal 2
Arc (Rattus norvegicus)
Fto (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 45 100.00 Very High Very High Very High
Body Weight 5 59.60 Quite High
Obesity 11 50.00 Quite Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low
Hyperphagia 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low
Appetite Loss 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, rather than manipulating Fto expression in specific ARC neuronal populations, we chose a strategy employing AAV mediated transfer of Fto cDNA and shRNA coupled with stereotactic injection in order to manipulate Fto expression within the ARC (Fig 1C).


ARC Positive_regulation (manipulate) of Gene_expression (expression) of Fto in neuronal associated with aids-related complex
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.80 Pain Relevance 0

General Comments

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