INT292992

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.78
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
Anatomy Link Frequency
cortex 2
nociceptors 2
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 246 99.48 Very High Very High Very High
unmyelinated 76 98.88 Very High Very High Very High
c fibre 84 98.86 Very High Very High Very High
Action potential 12 96.12 Very High Very High Very High
GABAergic 215 95.88 Very High Very High Very High
nociceptor 4 94.92 High High
antagonist 4 91.68 High High
Peripheral nerve injury 4 89.00 High High
Inflammatory mediators 2 87.28 High High
interneuron 2 85.76 High High
Disease Link Frequency Relevance Heat
Aging 51 98.64 Very High Very High Very High
Nervous System Injury 4 89.00 High High
INFLAMMATION 4 86.88 High High
Ganglion Cysts 26 84.84 Quite High
Lifespan 81 79.32 Quite High
Neuropathic Pain 8 75.20 Quite High
Anxiety Disorder 3 71.76 Quite High
Amblyopia 21 67.08 Quite High
Nociception 16 38.76 Quite Low
Cataract 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data establishes the functional expression of GABAA receptors in the axonal membrane of a sub-population of unmyelinated afferent human nerve fibres that most probably comprises nociceptors.
Negative_regulation (establishes) of Gene_expression (expression) of GABAA in nociceptors associated with nociceptor and unmyelinated
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.34 Pain Relevance 1.02
C-fibre responses to bath applied GABA (10 µM) were mediated by GABAA receptors, being mimicked by muscimol (10 µM, n?
Negative_regulation (mimicked) of Gene_expression (receptors) of GABAA associated with c fibre and gaba
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.81
In adult visual cortex, activity regulates GABAA receptor expression (Hendry et al., 1994) and during aging the loss of orientation tuning in visual cortical receptive fields (Leventhal et al., 2003) and changes in visual perception (Betts et al., 2005) have been linked with an overall loss of GABA.
Negative_regulation (regulates) of Gene_expression (expression) of GABAA receptor in cortex associated with gaba and aging
3) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.17 Pain Relevance 0.24
The current results show that in human V1 this transitional switch in expression of GABAA receptor subunits spans the critical period, when disrupting vision can cause long lasting changing in visual acuity (Lewis and Maurer, 2005).
Negative_regulation (switch) of Gene_expression (expression) of GABAA receptor
4) Confidence 0.10 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.07 Pain Relevance 0.10
The relative expression switched from more of the immature subunits (GABAA?
Negative_regulation (switched) of Gene_expression (expression) of GABAA
5) Confidence 0.10 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.21 Pain Relevance 0.24

General Comments

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