INT292993

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.90
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 279 99.90 Very High Very High Very High
spinal dorsal horn 6 99.44 Very High Very High Very High
unmyelinated 114 99.16 Very High Very High Very High
c fibre 126 99.10 Very High Very High Very High
GABAergic 150 95.16 Very High Very High Very High
Central nervous system 9 92.96 High High
antagonist 6 90.40 High High
Neuropathic pain 9 89.76 High High
dorsal root ganglion 39 84.48 Quite High
interneuron 3 84.28 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 96.60 Very High Very High Very High
Ganglion Cysts 39 84.48 Quite High
Lifespan 54 81.32 Quite High
Nociception 24 67.12 Quite High
Nervous System Injury 6 63.88 Quite High
INFLAMMATION 6 61.76 Quite High
Anxiety Disorder 2 52.80 Quite High
Amputation 3 33.04 Quite Low
Neuropathy 3 18.08 Low Low
Disease 3 12.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C-fibre responses to bath applied GABA (10 µM) were mediated by GABAA receptors, being mimicked by muscimol (10 µM, n?
Positive_regulation (mediated) of Gene_expression (receptors) of GABAA associated with c fibre and gaba
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.81
If the functional GABAA receptor expression in peripheral human unmyelinated axons extends further to the centrally projecting axons of sensory neurones, this observation provides considerable impetus for the translation of GABAA receptor targeted strategies to humans.


Positive_regulation (functional) of Gene_expression (expression) of GABAA receptor associated with unmyelinated
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.28 Pain Relevance 0.78
The increase in human C-fibre electrical excitability seen in response to GABA was mediated by GABAA receptors.
Positive_regulation (mediated) of Gene_expression (receptors) of GABAA associated with c fibre and gaba
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.38 Pain Relevance 0.82
In addition, there was a high level of GABAA?
Positive_regulation (level) of Gene_expression (high) of GABAA
4) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.05 Pain Relevance 0.17
2 balance was initially in favor of GABAA?
Positive_regulation (favor) of Gene_expression (favor) of GABAA
5) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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