INT293014

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6, CA2) cytoplasm (IRF6, CA2) extracellular space (CA2)
lyase activity (CA2) nucleus (IRF6) DNA binding (IRF6)
Anatomy Link Frequency
neutrophils 2
IRF6 (Homo sapiens)
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 206 99.84 Very High Very High Very High
opioid receptor 42 77.60 Quite High
Versed 1 34.72 Quite Low
opiate 5 34.08 Quite Low
cytokine 2 14.80 Low Low
narcan 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Codeine 5 5.00 Very Low Very Low Very Low
Endogenous opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 19 98.80 Very High Very High Very High
Sepsis 47 91.56 High High
Systemic Inflammatory Response Syndrome 7 51.16 Quite High
Stress 7 37.36 Quite Low
Sleep Disorders 3 32.80 Quite Low
Gram Positive Bacterium Infection 1 32.12 Quite Low
Critical Illness 4 12.52 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have demonstrated (i) that morphine is present in human neutrophils and is colocalized with lactoferrin, an antimicrobial peptide released during infection [42] from the secondary granules of neutrophils, (ii) that LPS and IL-8 trigger the Ca2+-dependent secretion of morphine and lactoferrin in vitro, (iii) that endogenous morphine concentrations are significantly increased in the serum of patients with septic conditions, (iv) that the concentration of morphine found in sepsis inhibits IL-8 release from neutrophils and finally (v) that ?
LPS Positive_regulation (trigger) of Localization (secretion) of Ca2 in neutrophils associated with sepsis, infection and morphine
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.71 Pain Relevance 1.02

General Comments

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