INT293047

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
iatrogenic 6 62.92 Quite High
Spinal cord 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 86 99.76 Very High Very High Very High
Disease 58 96.36 Very High Very High Very High
Creutzfeldt Jakob Disease 93 94.24 High High
Prion Diseases 27 88.84 High High
Targeted Disruption 57 78.12 Quite High
Genetic Predisposition To Disease 2 75.64 Quite High
Infection 19 40.44 Quite Low
Proteostasis Deficiencies 2 35.44 Quite Low
Neurodegenerative Disease 4 33.20 Quite Low
Alzheimer's Dementia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biophysical measurements suggest that this powerful effect of residue 129 on prion strain selection is likely to be mediated via its effect on the conformation of PrPSc or its precursors or on the kinetics of their formation, as it has no measurable effect on the folding, dynamics or stability of PrPC[5,174].
Protein_catabolism (stability) of PrPC associated with sprains and strains
1) Confidence 0.57 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.99 Pain Relevance 0.03
Because of its unique features, the SSLOW strain may prove to be a valuable model for addressing a number of puzzling questions of prion biology: what factors determine prion neurotropism; how strain-specific PrPSc structures control the rate of prion replication; why clinical disease could progresses so slowly despite large amounts of PrPSc deposition; and the physical nature of toxic versus infectious PrP isoforms.
Spec (determine) Protein_catabolism (neurotropism) of prion associated with disease and sprains and strains
2) Confidence 0.13 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 1.00 Pain Relevance 0

General Comments

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