INT293049

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.67
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 21 87.64 High High
Spinal cord 21 86.00 High High
Thalamus 9 45.04 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prion Diseases 81 100.00 Very High Very High Very High
Proteostasis Deficiencies 3 90.64 High High
Disease 102 89.84 High High
Neurodegenerative Disease 6 88.40 High High
Sprains And Strains 93 82.12 Quite High
Alzheimer's Dementia 18 75.64 Quite High
Neurological Disease 3 71.48 Quite High
Targeted Disruption 6 66.64 Quite High
Infection 24 62.00 Quite High
Creutzfeldt Jakob Disease 12 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies establish that transmissible prion disease can be induced in wild-type animals by inoculation of rPrP and introduce a valuable new model of prion diseases.
Positive_regulation (induced) of Localization (disease) of prion associated with prion diseases
1) Confidence 0.07 Published 2010 Journal Acta Neuropathol Section Abstract Doc Link PMC2808531 Disease Relevance 0.79 Pain Relevance 0.09
Surprisingly, the current study suggests that transmissible prion disease can be induced by a preparation of rPrP fibrils, which appear to be fundamentally different with respect to their global structure from PrPSc.
Positive_regulation (induced) of Localization (disease) of prion associated with prion diseases
2) Confidence 0.07 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 1.00 Pain Relevance 0
To date, attempts to generate transmissible prion disease in wild-type animals using rPrPs have not been successful despite numerous attempts in which rPrP was converted into a broad array of abnormal ?
Positive_regulation (generate) of Localization (disease) of prion associated with prion diseases
3) Confidence 0.07 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 0.87 Pain Relevance 0

General Comments

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