INT293099

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2005
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
kidney 2
Slc12a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 2 97.64 Very High Very High Very High
antagonist 6 92.32 High High
isoflurane 8 28.80 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 248 99.84 Very High Very High Very High
Hypertrophy 22 75.48 Quite High
Uremia 8 5.00 Very Low Very Low Very Low
Natriuresis 4 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 2 5.00 Very Low Very Low Very Low
Bartter Syndrome 2 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, densitometric analysis revealed that candesartan treatment significantly decreased whole kidney TSC expression in CRF rats (27±13% of sham-operated control level, p<0.05, Fig. 6, Table 2), whereas whole kidney TSC expression was unchanged in CRF rats treated with vehicle only (75±16% of sham-operated control level, n.s., Fig. 6, Table 2).


Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of TSC in kidney associated with chronic renal failure
1) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.23 Pain Relevance 0
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of TSC associated with chronic renal failure
2) Confidence 0.10 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.14

General Comments

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