INT293103

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
tubule 2
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 24.08 Low Low
bradykinin 2 9.04 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 32 98.40 Very High Very High Very High
Chronic Renal Failure 248 94.76 High High
Targeted Disruption 10 58.12 Quite High
Hypertrophy 22 53.44 Quite High
Natriuresis 4 28.96 Quite Low
Body Weight 8 28.36 Quite Low
Bartter Syndrome 2 7.56 Low Low
Hypercalcemia 4 5.64 Low Low
Uremia 8 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the proximal tubule of AngII-treated rats, the overall abundance of NHE3 and Na,K-ATPase remained unchanged.
Localization (abundance) of NHE3 in tubule
1) Confidence 0.58 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.33 Pain Relevance 0
Concomitant administration of high calcium diet and vitamin D3 also decreased protein abundance of NHE3, SGLT1, NKCC2, and NCC.
Localization (abundance) of NHE3
2) Confidence 0.56 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.21 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Localization (abundance) of NHE3 associated with kidney stones
3) Confidence 0.56 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.18 Pain Relevance 0
Consistent with this, the protein expression of NHE3, which is mainly localized at the apical membrane domains of the proximal tubule and plays a role in the sodium reabsorption, was significantly decreased in CRF rats treated with candesartan compared with CRF rats treated with vehicle but the GFR between the two groups was not different.
Localization (localized) of NHE3 in tubule associated with chronic renal failure
4) Confidence 0.54 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.39 Pain Relevance 0

General Comments

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