INT293104

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.99
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
ascending limbs 1
brush 1
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 56.08 Quite High
bradykinin 2 41.04 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 248 92.16 High High
Hypertrophy 22 85.44 High High
Body Weight 12 73.36 Quite High
Kidney Stones 48 70.80 Quite High
Natriuresis 4 40.96 Quite Low
Targeted Disruption 14 13.12 Low Low
Uremia 8 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 6 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Hematuria 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously demonstrated that chronic infusion of supraphysiological doses of AngII in normal rats was associated with significantly increased abundance and apical expression level of the Na-H exchanger NHE3 and Na-K-2Cl cotransporter BSC-1 in medullary thick ascending limbs (mTAL), whereas Na,K-ATPase and electroneutral Na-HCO3 cotransporter (NBCn1) levels remained unchanged (10).
Transcription (abundance) of Na-H exchanger NHE3 in ascending limbs
1) Confidence 0.53 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.32 Pain Relevance 0
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Transcription (abundance) of NHE3 in brush
2) Confidence 0.53 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.35 Pain Relevance 0.05
Protein abundance of NHE3, NKCC2, and NCC was decreased in the high Ca-vitamin D group and was not changed by HCTZ.
Transcription (abundance) of NHE3
3) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0
Expression of NHE3, SGLT1, and NKCC2 mRNA was significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered. mRNA expression results are summarized in Table 3.


Transcription (Expression) of NHE3
4) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0
Protein abundance of NHE3, SGLT1, and NKCC2 decreased in the hypercalciuric rats, and only SGLT1 protein abundance was increased by HCTZ in the hypercalciuric rats.
Transcription (abundance) of NHE3
5) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923802 Disease Relevance 0.07 Pain Relevance 0

General Comments

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