INT293106

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.81
Pain Relevance 0

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plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
Kidney 4
ascending limb 2
tubule 2
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 18 28.32 Quite Low
isoflurane 24 5.00 Very Low Very Low Very Low
anesthesia 20 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 744 99.84 Very High Very High Very High
Hypertrophy 66 95.58 Very High Very High Very High
Polyuria 6 80.60 Quite High
Uremia 24 79.60 Quite High
Body Weight 4 73.36 Quite High
Targeted Disruption 10 63.44 Quite High
Kidney Stones 16 52.16 Quite High
Disorders Of Creatine Metabolism 6 13.68 Low Low
Bartter Syndrome 6 8.12 Low Low
Hypercalcemia 7 6.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this, the protein expression of NHE3, which is mainly localized at the apical membrane domains of the proximal tubule and plays a role in the sodium reabsorption, was significantly decreased in CRF rats treated with candesartan compared with CRF rats treated with vehicle but the GFR between the two groups was not different.
Negative_regulation (decreased) of Gene_expression (expression) of NHE3 in tubule associated with chronic renal failure
1) Confidence 0.45 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.42 Pain Relevance 0
The decreased AQP2 expression in CRF rats was not altered in response to candesartan treatment; 3) Candesartan treatment was associated with decreased NHE3 and TSC expression in CRF, which could be due to the Ang II AT1 receptor blockade and/or decreased aldosterone levels; and 4) BSC-1 expression was increased in both CRF groups and the increased expression of BSC-1 was more prominent in candesartan-treated CRF rats compared with vehicle-treated CRF rats.
Negative_regulation (decreased) of Gene_expression (expression) of NHE3 associated with chronic renal failure
2) Confidence 0.45 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.28 Pain Relevance 0
Candesartan treatment significantly decreased whole kidney NHE3 expression in CRF rats (25±5% of sham-operated control level, p<0.05, Fig. 5, Table 2), whereas whole kidney NHE3 expression was unchanged in CRF rats treated with vehicle only (76±16% of sham-operated control level, n.s., Fig. 5, Table 2).
Negative_regulation (decreased) of Gene_expression (expression) of NHE3 in kidney associated with chronic renal failure
3) Confidence 0.45 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.19 Pain Relevance 0
In contrast, the expression of NHE3 (25%) and TSC (27%) was decreased in CRF-C, whereas no changes were observed in CRF-V.
Negative_regulation (decreased) of Gene_expression (expression) of NHE3 associated with chronic renal failure
4) Confidence 0.33 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.90 Pain Relevance 0
In conclusion, 1) candesartan treatment in an early phase of CRF is associated with decreased renal hypertrophy and increased BUN level; 2) decreased AQP2 level in CRF is likely to play a role in the decreased urine concentration, and the downregulation is not altered in response to candesartan treatment; 3) candesartan treatment decreases NHE3 and TSC expression; and 4) an increase of BSC-1 is prominent in candesartan-treated CRF rats, which could be associated with the increased delivery of sodium and water to the thick ascending limb.



Negative_regulation (decreases) of Gene_expression (expression) of NHE3 in ascending limb associated with hypertrophy and chronic renal failure
5) Confidence 0.33 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.55 Pain Relevance 0
Kidney expression of NHE3 and TSC was decreased in CRF rats treated with candesartan (CRF-C)
Negative_regulation (decreased) of Gene_expression (expression) of NHE3 in Kidney associated with chronic renal failure
6) Confidence 0.33 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.35 Pain Relevance 0
Expression of NHE3, SGLT1, and NKCC2 mRNA was significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered. mRNA expression results are summarized in Table 3.


Negative_regulation (decreased) of Gene_expression (Expression) of NHE3
7) Confidence 0.32 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0

General Comments

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