INT293112

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
Kidney 4
Slc12a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 9 28.32 Quite Low
isoflurane 12 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 372 99.84 Very High Very High Very High
Hypertrophy 33 57.12 Quite High
Disorders Of Creatine Metabolism 3 13.68 Low Low
Uremia 12 11.16 Low Low
Natriuresis 6 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low
Bartter Syndrome 3 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kidney expression of NHE3 and TSC was decreased in CRF rats treated with candesartan (CRF-C)
Negative_regulation (decreased) of Gene_expression (expression) of TSC in Kidney associated with chronic renal failure
1) Confidence 0.15 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.35 Pain Relevance 0
Moreover, densitometric analysis revealed that candesartan treatment significantly decreased whole kidney TSC expression in CRF rats (27±13% of sham-operated control level, p<0.05, Fig. 6, Table 2), whereas whole kidney TSC expression was unchanged in CRF rats treated with vehicle only (75±16% of sham-operated control level, n.s., Fig. 6, Table 2).


Negative_regulation (decreased) of Gene_expression (expression) of TSC in kidney associated with chronic renal failure
2) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.25 Pain Relevance 0
The decreased AQP2 expression in CRF rats was not altered in response to candesartan treatment; 3) Candesartan treatment was associated with decreased NHE3 and TSC expression in CRF, which could be due to the Ang II AT1 receptor blockade and/or decreased aldosterone levels; and 4) BSC-1 expression was increased in both CRF groups and the increased expression of BSC-1 was more prominent in candesartan-treated CRF rats compared with vehicle-treated CRF rats.
Negative_regulation (decreased) of Gene_expression (expression) of TSC associated with chronic renal failure
3) Confidence 0.11 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.28 Pain Relevance 0

General Comments

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