INT293158

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.62
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRAF1) protein complex assembly (TRAF1) cytoplasm (TRAF1)
TRAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 304 99.80 Very High Very High Very High
rheumatoid arthritis 156 97.40 Very High Very High Very High
Inflammation 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 288 99.80 Very High Very High Very High
Rheumatoid Arthritis 156 97.40 Very High Very High Very High
Arthritis 20 50.44 Quite High
Disease Susceptibility 8 50.00 Quite Low
Autoimmune Disease 44 6.92 Low Low
Disease 56 5.00 Very Low Very Low Very Low
Demyelinating Disease 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Rheumatic Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, a recent study of Dutch JIA cases and controls investigated the rs10818488 SNP in the TRAF1/C5 region,27 and found no evidence for association of this SNP in patients with JIA as a whole.
Spec (investigated) Gene_expression (region,27) of TRAF1 associated with arthritis
1) Confidence 0.63 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 1.29 Pain Relevance 0.64
The lack of consistency between studies of TRAF1/C5 region and JIA susceptibility may be due to the lack of power of individual studies to detect the modest effect sizes reported at this locus.
Gene_expression (region) of TRAF1 associated with arthritis
2) Confidence 0.63 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.64 Pain Relevance 0.32
A second, small study of SNPs within TRAF1/C5 region in USA JIA cases also reported association with this region.
Gene_expression (region) of TRAF1 associated with arthritis
3) Confidence 0.63 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.89 Pain Relevance 0.44
TRAF1/C5: Three SNPs located in the TRAF1/C5 region were identified for investigation, one of which (rs10818488) showed the strongest evidence for association with Dutch RA cases.15 The other two SNPs, rs3761847 and rs2900180, showed the strongest evidence for association in North American and Swedish RA cases.16
Gene_expression (region) of TRAF1 associated with rheumatoid arthritis
4) Confidence 0.63 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.81 Pain Relevance 0.41
The minimal information which is required for a ChEBI submission is a name, which must be unique within the database, either a text definition or a chemical structure and a primary classification within the ontology.
Gene_expression (submission) of ChEBI
5) Confidence 0.56 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808869 Disease Relevance 0 Pain Relevance 0

General Comments

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