INT293188

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.46
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 1
muscle 1
myotubes 1
MIR206 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 52 95.28 Very High Very High Very High
lidocaine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
local anesthetic 4 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 69 95.84 Very High Very High Very High
Impaired Glucose Tolerance 52 95.28 Very High Very High Very High
Diabetes Mellitus 317 94.08 High High
Deafness 1 90.72 High High
Blastoma 1 86.40 High High
Hypertrophy 4 81.12 Quite High
Insulin Resistance 140 70.44 Quite High
Hyperinsulinism 8 7.44 Low Low
Obesity 28 5.00 Very Low Very Low Very Low
Metabolic Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over-expression of miR-1 [55] or miR-206 [86] in mouse myoblasts accelerates differentiation into myotubes whereas over-expression of miR-133 promotes proliferation [55].
Gene_expression (expression) of miR-206 in myotubes
1) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.49 Pain Relevance 0
ANOVA indicated that miR-133a (F = 11.8, P < 0.0001) was significantly different between the three groups, miR-206 expression more modestly altered (F = 4.5, P = 0.02) and miR-1 and miR-133b were unchanged (Figure 2c).
Gene_expression (expression) of miR-206
2) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.70 Pain Relevance 0.05
Interestingly, reduction in miR-133a using an antagomir (Figure S4A in Additional file 1) had an indirect effect on the other myomirs, such that miR-133b (expected due to sequence similarity) and miR-206 (unexpected) were substantially reduced.
Gene_expression (unexpected) of miR-206
3) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle.
Gene_expression (expression) of miR-206 in muscle
4) Confidence 0.17 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
-UTR of the ovine MSTN gene that causes increased muscle mass by creating an illegitimate target site for coexpressed miR-1 and miR-206 (1), and the report of >10 associations of polymorphisms in miRNA target sites (poly-miRTS) with human disease [reviewed in (2)], (ii) the identification of mutations in the seed region of human miR-96 responsible for nonsyndromic progressive hearing loss (3,4) and (iii) the identification of DICER1 mutations in familial pleuropulmonary blastoma (5).
Gene_expression (coexpressed) of miR-206 in poly associated with deafness, blastoma and disease
5) Confidence 0.07 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.27 Pain Relevance 0

General Comments

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