INT293188

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 1.46 Pain Relevance 0.05

Anatomy Link Frequency poly 1 muscle 1 myotubes 1 MIR206 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 52 95.28 lidocaine 4 5.00 withdrawal 4 5.00 cINOD 4 5.00 Pain 4 5.00 Potency 4 5.00 local anesthetic 4 5.00 spastic colon 1 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Disease 69 95.84 Impaired Glucose Tolerance 52 95.28 Diabetes Mellitus 317 94.08 Deafness 1 90.72 Blastoma 1 86.40 Hypertrophy 4 81.12 Insulin Resistance 140 70.44 Hyperinsulinism 8 7.44 Obesity 28 5.00 Metabolic Disorder 8 5.00

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Over-expression of miR-1 [55] or miR-206 [86] in mouse myoblasts accelerates differentiation into myotubes whereas over-expression of miR-133 promotes proliferation [55].

Gene_expression (expression) of miR-206 in myotubes

1) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.49 Pain Relevance 0

ANOVA indicated that miR-133a (F = 11.8, P < 0.0001) was significantly different between the three groups, miR-206 expression more modestly altered (F = 4.5, P = 0.02) and miR-1 and miR-133b were unchanged (Figure 2c).

Gene_expression (expression) of miR-206

2) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.70 Pain Relevance 0.05

Interestingly, reduction in miR-133a using an antagomir (Figure S4A in Additional file 1) had an indirect effect on the other myomirs, such that miR-133b (expected due to sequence similarity) and miR-206 (unexpected) were substantially reduced.

Gene_expression (unexpected) of miR-206

3) Confidence 0.19 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0

Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle.

Gene_expression (expression) of miR-206 in muscle

4) Confidence 0.17 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0

-UTR of the ovine MSTN gene that causes increased muscle mass by creating an illegitimate target site for coexpressed miR-1 and miR-206 (1), and the report of >10 associations of polymorphisms in miRNA target sites (poly-miRTS) with human disease [reviewed in (2)], (ii) the identification of mutations in the seed region of human miR-96 responsible for nonsyndromic progressive hearing loss (3,4) and (iii) the identification of DICER1 mutations in familial pleuropulmonary blastoma (5).

Gene_expression (coexpressed) of miR-206 in poly associated with deafness, blastoma and disease

5) Confidence 0.07 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.27 Pain Relevance 0

General Comments

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