INT293188
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Over-expression of miR-1 [55] or miR-206 [86] in mouse myoblasts accelerates differentiation into myotubes whereas over-expression of miR-133 promotes proliferation [55]. | |||||||||||||||
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ANOVA indicated that miR-133a (F = 11.8, P < 0.0001) was significantly different between the three groups, miR-206 expression more modestly altered (F = 4.5, P = 0.02) and miR-1 and miR-133b were unchanged (Figure 2c). | |||||||||||||||
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Interestingly, reduction in miR-133a using an antagomir (Figure S4A in Additional file 1) had an indirect effect on the other myomirs, such that miR-133b (expected due to sequence similarity) and miR-206 (unexpected) were substantially reduced. | |||||||||||||||
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Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle. | |||||||||||||||
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-UTR of the ovine MSTN gene that causes increased muscle mass by creating an illegitimate target site for coexpressed miR-1 and miR-206 (1), and the report of >10 associations of polymorphisms in miRNA target sites (poly-miRTS) with human disease [reviewed in (2)], (ii) the identification of mutations in the seed region of human miR-96 responsible for nonsyndromic progressive hearing loss (3,4) and (iii) the identification of DICER1 mutations in familial pleuropulmonary blastoma (5). | |||||||||||||||
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