INT29322

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.31
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
brain 1
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 13 99.84 Very High Very High Very High
B1 receptor 97 99.82 Very High Very High Very High
Enkephalin 11 99.76 Very High Very High Very High
Dorsal horn 5 99.74 Very High Very High Very High
narcan 3 99.56 Very High Very High Very High
Spinal cord 29 99.20 Very High Very High Very High
Hippocampus 2 87.92 High High
cerebral cortex 1 87.28 High High
Serotonin 2 83.08 Quite High
fluoxetine 2 81.96 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 74.88 Quite High
INFLAMMATION 13 73.76 Quite High
Diabetes Mellitus 65 52.12 Quite High
Stress 3 51.12 Quite High
Pain 12 50.00 Quite Low
Hyperglycemia 8 46.28 Quite Low
Neuropathic Pain 64 30.24 Quite Low
Hyperalgesia 21 29.12 Quite Low
Nociception 8 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain.
Negative_regulation (reduction) of sites in brain
1) Confidence 0.37 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.42
Binding of 3H-naloxone to the mu 1 and mu 2 sites was differentially inhibited by opioids.
Negative_regulation (inhibited) of sites associated with narcan and opioid
2) Confidence 0.02 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.44
A 3 h treatment with fluorocitrate normalized B1R mRNA level, yet specific dorsal horn B1R binding sites were reduced by only 38% in the spinal cord of STZ rats.
Negative_regulation (reduced) of sites in spinal cord associated with b1 receptor, dorsal horn and spinal cord
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.31 Pain Relevance 0.97
When mu sites were blocked with DAGO, the Fab fragments suppressed the binding of [3H]DPDPE to the same degree as when the mu binding sites was not blocked.
Negative_regulation (blocked) of sites associated with enkephalin
4) Confidence 0.00 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828974 Disease Relevance 0 Pain Relevance 0.77
When mu sites were blocked with DAGO, the Fab fragments suppressed the binding of [3H]DPDPE to the same degree as when the mu binding sites was not blocked.
Negative_regulation (blocked) of sites associated with enkephalin
5) Confidence 0.00 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828974 Disease Relevance 0 Pain Relevance 0.76

General Comments

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