INT293249

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
Anatomy Link Frequency
regulatory T lymphocytes 1
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.42 Very High Very High Very High
Inflammation 16 99.22 Very High Very High Very High
cINOD 42 97.44 Very High Very High Very High
Central nervous system 10 87.84 High High
Multiple sclerosis 19 81.68 Quite High
corticosteroid 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 20 99.22 Very High Very High Very High
Infection 4 93.28 High High
Recurrence 8 91.48 High High
Demyelinating Disease 20 81.68 Quite High
Disease 20 57.52 Quite High
Multiple Sclerosis 5 47.24 Quite Low
Bronchopulmonary Dysplasia 1 41.84 Quite Low
Neurological Disease 3 17.40 Low Low
Stroke 3 5.00 Very Low Very Low Very Low
Thrombosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the immune response evolves, the increase in the production of pro-inflammatory cytokines such as IFNs stimulates the secretion of IDO by pDCs, which in turn will activate regulatory T lymphocytes.
Localization (secretion) of IDO in regulatory T lymphocytes associated with inflammation and cytokine
1) Confidence 0.38 Published 2011 Journal J Neuroinflammation Section Body Doc Link PMC3022734 Disease Relevance 0.77 Pain Relevance 0.36
However, Indo increased solubilization of pure DOPC bilayers (Fig. 4C), opposite of the effect of the NSAID on the mixed membrane or pure DPPC.
Localization (solubilization) of Indo associated with cinod
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.18
This suggests that Indo induced less lipid solublization and led to an increased detergent resistance for DPPC and more solubilization of DOPC.
Localization (solubilization) of Indo
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809093 Disease Relevance 0 Pain Relevance 0.14

General Comments

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