INT293259

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
cleavage 2
synaptic vesicle 2
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 96.52 Very High Very High Very High
backache 8 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 10 99.64 Very High Very High Very High
Schizophrenia 14 99.32 Very High Very High Very High
Disease 390 98.76 Very High Very High Very High
Glioblastoma 6 95.28 Very High Very High Very High
Uterine Fibroids 8 92.24 High High
Neuroblastoma 1 91.44 High High
Benign Tumor 2 90.56 High High
Lung Cancer 10 82.72 Quite High
Brain Disease 4 80.20 Quite High
Poisoning 3 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of synaptic functions and more specifically, decreased expression of synaptic vesicle proteins such as SNAP-25 is one of the main effects of ALZ [13],[14].
Negative_regulation (decreased) of Gene_expression (expression) of SNAP-25 in synaptic vesicle associated with disease
1) Confidence 0.49 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 2.53 Pain Relevance 0.05
In particular, the levels of protein SNAP-25 was shown to be reduced in both BIP and SCHZ [17].
Negative_regulation (reduced) of Gene_expression (levels) of protein SNAP-25 associated with manic depressive disorder and schizophrenia
2) Confidence 0.43 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 2.39 Pain Relevance 0.04
Analysis of NP-specific marker genes in degenerate samples (Figure 6a) showed a significant decrease in expression for SNAP25, KRT8, KRT18 and CDH2 in degenerate NP cells when compared with normal NP cells (P = 0.0002, P = 0.0003, P < 0.0001 and P = 0.0001, respectively).
Negative_regulation (decrease) of Gene_expression (expression) of SNAP25
3) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
We concentrated on our anti-A clones and show that six of the anti-A clones (A1, A2, A8, A9, A16, A17) demonstrate reduced SNAP-25 cleavage by virtue of a decrease in the amount of ?
Negative_regulation (reduced) of Gene_expression (cleavage) of SNAP-25 in cleavage
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0.16 Pain Relevance 0

General Comments

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