INT29326

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.71
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Calm1)
Anatomy Link Frequency
tail 2
neurons 1
umbilical vein 1
T-cell 1
Calm1 (Mus musculus)
Calm1 - E140K (1)
Pain Link Frequency Relevance Heat
opiate 2 99.96 Very High Very High Very High
agonist 11 99.68 Very High Very High Very High
antinociception 8 99.40 Very High Very High Very High
chemokine 12 99.36 Very High Very High Very High
antagonist 4 99.20 Very High Very High Very High
cytokine 6 99.08 Very High Very High Very High
tail-flick 4 97.56 Very High Very High Very High
Action potential 98 96.40 Very High Very High Very High
sodium channel 16 95.12 Very High Very High Very High
Inflammation 10 91.04 High High
Disease Link Frequency Relevance Heat
Adhesions 9 99.80 Very High Very High Very High
Phobia 7 98.78 Very High Very High Very High
Infection 47 97.56 Very High Very High Very High
Necrosis 3 88.68 High High
Cancer 3 88.32 High High
Sprains And Strains 20 87.84 High High
INFLAMMATION 13 86.04 High High
Osteoarthritis 42 84.80 Quite High
Cytomegalovirus Infection 12 80.48 Quite High
Targeted Disruption 11 72.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAM has been shown to produce opiate agonist and antagonist activities.
Gene_expression (produce) of CAM associated with antagonist, agonist and opiate
1) Confidence 0.67 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828975 Disease Relevance 0 Pain Relevance 0.63
Each of the nine categories was included as an outcome of interest, as well as one summary outcome to denote whether an individual ever used any of the categories (ever used CAM) for a total of ten outcomes.
Gene_expression (used) of CAM
2) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0.08 Pain Relevance 0.04
And finally 4) How do these interactions play into the use of CAM?
Gene_expression (use) of CAM
3) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0.07 Pain Relevance 0
2) Are patients substituting CAM for conventional treatment?
Gene_expression (substituting) of CAM
4) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0 Pain Relevance 0
The association between medical skepticism and some types of CAM use begs the following questions: 1) What are the consequences of the relationship between medical skepticism and the use of CAM?
Gene_expression (use) of CAM
5) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0 Pain Relevance 0
Although fear of disapproval was rarely cited as a reason for not discussing CAM use in one study, the authors found that one of the most common reasons for not disclosing CAM use was that the physician had not requested that information [9].
Neg (not) Gene_expression (use) of CAM associated with phobia
6) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0.10 Pain Relevance 0
Most of the other characteristics were significant in some, but not all, of the models, as is shown by the results from one of the models (ever use of CAM) in Table 3 (other models are not shown here).
Gene_expression (use) of CAM
7) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0 Pain Relevance 0
Although fear of disapproval was rarely cited as a reason for not discussing CAM use in one study, the authors found that one of the most common reasons for not disclosing CAM use was that the physician had not requested that information [9].
Neg (not) Gene_expression (use) of CAM associated with phobia
8) Confidence 0.59 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581824 Disease Relevance 0.10 Pain Relevance 0
PRV369 infected cells express G-CaMP2
Gene_expression (express) of CaM
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735035 Disease Relevance 0.56 Pain Relevance 0.04
PRV 369 was constructed by homologous recombination between a plasmid containing a G-CaMP2 expression cassette and the gG locus of the PRV-Bartha genome.
Gene_expression (expression) of CaM
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735035 Disease Relevance 0.66 Pain Relevance 0
This effect appears to be mediated through inhibition of cytokine and chemokine release and down-regulation of CAM expression.
Gene_expression (expression) of CAM associated with chemokine and cytokine
11) Confidence 0.27 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.44 Pain Relevance 0.28
In the mouse 55 degrees C warm water tail-flick test, both CACO and N-CPM-CACO acted as short-term mu-selective agonists when administered by i. c.v. injection, whereas CAM and MC-CAM produced no measurable antinociception at doses up to 30 nmol.
Neg (no) Gene_expression (produced) of MC-CAM in tail associated with antinociception, agonist and tail-flick
12) Confidence 0.26 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087018 Disease Relevance 0 Pain Relevance 0.98
In the mouse 55 degrees C warm water tail-flick test, both CACO and N-CPM-CACO acted as short-term mu-selective agonists when administered by i. c.v. injection, whereas CAM and MC-CAM produced no measurable antinociception at doses up to 30 nmol.
Neg (no) Gene_expression (produced) of CAM in tail associated with antinociception, agonist and tail-flick
13) Confidence 0.26 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087018 Disease Relevance 0 Pain Relevance 0.98
In human umbilical vein endothelial cells (HUVECs), budlein A also reduced the production of TNF-alpha, monocyte chemoattractant protein-1 (MCP-1), IL-8, nitrites and CAM expression elicited by LPS.
Gene_expression (expression) of CAM in umbilical vein
14) Confidence 0.24 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.59 Pain Relevance 0.38
In vitro, the effects of budlein A on LPS-induced cytokine, chemokine and nitrites release, T-cell proliferative response as well as cell adhesion molecule expression (CAM) were evaluated.
Gene_expression (expression) of CAM in T-cell associated with chemokine, adhesions and cytokine
15) Confidence 0.24 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.64 Pain Relevance 0.33
Contactin is a glycosyl-phosphatidylinositol-anchored CAM protein expressed by neurons.
Gene_expression (expressed) of CAM protein in neurons
16) Confidence 0.01 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.46 Pain Relevance 0.39
Previous versions of GCaMP yielded lower levels of detection (GCaMP1.6, GCaMP1.6-CAM(E140K); Figure 5), illustrating the improvement of GCaMP2 over its predecessors.


Gene_expression (detection) of GCaMP1.6-CAM (E140K)
17) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262942 Disease Relevance 0 Pain Relevance 0.48

General Comments

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