INT29327

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 8.79
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
macrophages 1
muscle 1
capillary 1
striatum 1
lung 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 99.92 Very High Very High Very High
Enkephalin 15 99.84 Very High Very High Very High
Multiple sclerosis 6 99.84 Very High Very High Very High
Peripheral nervous system 8 99.76 Very High Very High Very High
Calcium channel 6 99.32 Very High Very High Very High
narcan 5 99.12 Very High Very High Very High
Neuritis 2 96.24 Very High Very High Very High
opioid receptor 3 95.76 Very High Very High Very High
Opioid 3 93.92 High High
ischemia 2 93.52 High High
Disease Link Frequency Relevance Heat
Dermatitis 8 100.00 Very High Very High Very High
INFLAMMATION 44 99.92 Very High Very High Very High
Lung Injury 39 99.84 Very High Very High Very High
Demyelinating Disease 10 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 2 99.70 Very High Very High Very High
Colon Cancer 82 99.68 Very High Very High Very High
Metastasis 80 99.52 Very High Very High Very High
Urological Neuroanatomy 6 98.40 Very High Very High Very High
Cancer 151 98.32 Very High Very High Very High
Hypertension 11 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three peptides dose -dependently inhibited ACE activity in vitro except 10(-5) M concentration of BETA-END which increased the lung ACE activity.
Neg (except) Positive_regulation (increased) of ACE in lung
1) Confidence 0.67 Published 1986 Journal Pharmacol Res Commun Section Abstract Doc Link 3014570 Disease Relevance 0 Pain Relevance 0.65
In the striatum, a highly significant increase in the ACE mRNA amount was detected after 3 weeks of removal of ethanol in C57BL/6 mice, whereas in DBA/2 mice the delta-opioid receptor mRNA level was increased at this time when compared with the corresponding ethanol treatment group.
Positive_regulation (increase) of ACE mRNA in striatum associated with opioid receptor
2) Confidence 0.64 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.34 Pain Relevance 0.45
In 2,4-dinitro-1-fluorobenzene-sensitized ACE(+/-) mice, ACD was significantly augmented in comparison to ACE(+/+) controls as determined by the degree of ear swelling after exposure to hapten.
Positive_regulation (augmented) of ACE in ear associated with pressure and volume under development and dermatitis
3) Confidence 0.49 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12646655 Disease Relevance 1.14 Pain Relevance 0.53
In hypertensive patients various anti-hypertensive drugs were investigated in crossover studies (morning vs. evening dosing); however consistent data were only obtained for angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers.
Positive_regulation (obtained) of ACE associated with calcium channel and hypertension
4) Confidence 0.44 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16480770 Disease Relevance 1.32 Pain Relevance 0.50
ACE can also be elevated in MS.
Positive_regulation (elevated) of ACE associated with multiple sclerosis
5) Confidence 0.43 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10863022 Disease Relevance 1.10 Pain Relevance 0.61
We show a marked up-regulation of ACE during CRC metastases development, which would presumably favor CRC metastases growth by increasing production of ANG II.
Positive_regulation (regulation) of ACE associated with colon cancer and metastasis
6) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.33 Pain Relevance 0
Moreover, IC50 values against "enkephalinase" were found in the same range whatever the length of the chain bearing the carboxyl group whereas a well-defined position of this group with respect to the Zn atom is required for strong ACE inhibition.
Positive_regulation (required) of ACE
7) Confidence 0.32 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298535 Disease Relevance 0 Pain Relevance 0.16
This is reflected in the fact that adults with severe peripheral vascular disease significantly increase their walking time following treatment with ACE inhibitors.118
Positive_regulation (increase) of ACE associated with increased venous pressure under development
8) Confidence 0.30 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938029 Disease Relevance 0.59 Pain Relevance 0
BAL total protein levels and ACE activity were also elevated by VILI, indicating compromise of the alveolo-capillary barrier.
Positive_regulation (elevated) of ACE in capillary associated with lung injury
9) Confidence 0.23 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887192 Disease Relevance 0.69 Pain Relevance 0.13
We investigated the ability of central (CNS) and peripheral nervous system (PNS) myelin to stimulate TNF, interleukin-12, and ACE production by murine macrophages.
Spec (investigated) Positive_regulation (stimulate) of ACE in macrophages associated with peripheral nervous system
10) Confidence 0.19 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10863022 Disease Relevance 1.04 Pain Relevance 0.62
Overall, these findings suggest that, in order to deliver short chain peptides intraocularly from topical solution instillation, it will be necessary to control the ocular tissue activity of aminopeptidases principally and, to a lesser extent, the activity of dipeptidyl peptidase and dipeptidyl carboxylpeptidase.
Positive_regulation (necessary) of dipeptidyl carboxylpeptidase
11) Confidence 0.13 Published 1986 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 3733372 Disease Relevance 0 Pain Relevance 0.20
Overall, these findings suggest that, in order to deliver short chain peptides intraocularly from topical solution instillation, it will be necessary to control the ocular tissue activity of aminopeptidases principally and, to a lesser extent, the activity of dipeptidyl peptidase and dipeptidyl carboxylpeptidase.
Positive_regulation (necessary) of dipeptidyl peptidase
12) Confidence 0.13 Published 1986 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 3733372 Disease Relevance 0 Pain Relevance 0.20
In CHF, inhibition of the angiotensin-converting enzyme (ACE) by administration of enalapril reduces the risk of weight loss and it is linked to improved survival.93 Preliminary results demonstrate increased subcutaneous fat (increased skin fold thickness) and greater muscle bulk (increased mid-upper arm and tight circumferences), together with a significant elevation in plasma albumin and hematocrit.94 ACE inhibitors, like captopril, seem to act by decreasing the production of TNF-?
Positive_regulation (elevation) of ACE in muscle associated with appetite loss and myocardial infarction
13) Confidence 0.12 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 1.24 Pain Relevance 0
Inactivation of [Leu5]-enkephalin in three isolated preparations: relative importance of aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A.
Positive_regulation (importance) of peptidyl dipeptidase associated with enkephalin
14) Confidence 0.07 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2828976 Disease Relevance 0 Pain Relevance 0.29

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