INT293307

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.77
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
body 4
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
behavioral therapy 14 69.12 Quite High
Bile 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 100.00 Very High Very High Very High
Body Weight 85 99.50 Very High Very High Very High
Obesity 26 98.16 Very High Very High Very High
Hyperlipidemia 19 97.24 Very High Very High Very High
Hyperlipoproteinemia Type Ii 66 96.46 Very High Very High Very High
Overweight 11 83.40 Quite High
Erythema 1 76.40 Quite High
Hyperphagia 8 75.04 Quite High
Cold Sores 1 47.44 Quite Low
Epstein-barr Virus 4 19.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the majority of studies were focused on treating FH by inhibition of hypercholesterolaemia through up-regulation of LDLR or other surrogate lipoprotein receptors (as will be discussed later), an alternative approach was to down-regulate apoB-100 LDLR-ligand or PCSK9 [63] expression.
Regulation (regulate) of Gene_expression (expression) of LDLR associated with hyperlipoproteinemia type ii and hyperlipidemia
1) Confidence 0.19 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.36 Pain Relevance 0
Several body weight loss interventions have reported improvements on serum TC, HDL-cholesterol and LDL-cholesterol levels (Lee et al., 2005) and improvements in TC and LDL-cholesterol levels (Seo, 2005), besides improvements in HDL-cholesterol levels (Lee et al., 2007) with aerobic exercise in middle-aged women.
Regulation (reported) of Gene_expression (levels) of LDL-cholesterol in body associated with body weight and disorder of lipid metabolism
2) Confidence 0.17 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 1.21 Pain Relevance 0.03
Several body weight loss interventions have reported improvements on serum TC, HDL-cholesterol and LDL-cholesterol levels (Lee et al., 2005) and improvements in TC and LDL-cholesterol levels (Seo, 2005), besides improvements in HDL-cholesterol levels (Lee et al., 2007) with aerobic exercise in middle-aged women.
Regulation (reported) of Gene_expression (levels) of LDL-cholesterol in body associated with body weight and disorder of lipid metabolism
3) Confidence 0.17 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 1.20 Pain Relevance 0.03

General Comments

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