INT29331

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Context Info
Confidence 0.21
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.65
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
substantia nigra 1
spinal cord 1
neural lobe 1
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 194 100.00 Very High Very High Very High
Substantia nigra 1 99.84 Very High Very High Very High
Spinal cord 59 99.32 Very High Very High Very High
Pyramidal cell 1 98.52 Very High Very High Very High
Central grey 1 96.56 Very High Very High Very High
opioid receptor 5 93.24 High High
opiate 4 92.40 High High
medulla 2 88.88 High High
antagonist 42 88.80 High High
Thermal hyperalgesia 16 88.56 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 130 99.84 Very High Very High Very High
Urological Neuroanatomy 1 96.56 Very High Very High Very High
Hyperalgesia 42 88.56 High High
Hyperglycemia 16 86.16 High High
Stress 6 75.92 Quite High
Neuropathic Pain 128 63.80 Quite High
Pain 24 63.36 Quite High
INFLAMMATION 26 60.56 Quite High
Nociception 16 15.28 Low Low
Nervous System Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The substantia nigra showed up-regulation of kappa but not of mu sites.
Positive_regulation (up-regulation) of sites in substantia nigra associated with substantia nigra
1) Confidence 0.21 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0.10 Pain Relevance 0.95
The monkey neural lobe was found to contain all three subtypes with a preponderance of kappa sites, while the rat and bovine neurohypophyses contained only kappa sites.
Positive_regulation (preponderance) of sites in neural lobe
2) Confidence 0.01 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828979 Disease Relevance 0 Pain Relevance 0.30
We observed an upregulation of both B1R binding sites and mRNA in the spinal cord of STZ-diabetic rats in comparison with its low level of expression in controls.
Positive_regulation (upregulation) of sites in spinal cord associated with diabetes mellitus, b1 receptor and spinal cord
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.82 Pain Relevance 0.62
Fluorocitrate (1 nmol, i.t.) administered in STZ-diabetic rats, 3 h prior sacrifice, reduced (-38%) the increased density of specific B1R binding sites induced by diabetes to values (1.532 fmol/mg protein) not significantly different from control density (Figure 4).


Positive_regulation (induced) of sites associated with diabetes mellitus and b1 receptor
4) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.73 Pain Relevance 0.82

General Comments

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