INT293311

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.99
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 81.04 Quite High
Inflammation 21 31.76 Quite Low
cva 7 19.04 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 58 98.04 Very High Very High Very High
Increased Venous Pressure Under Development 5 95.96 Very High Very High Very High
Stress 30 93.56 High High
Toxicity 44 86.16 High High
Hyperlipidemia 6 85.12 High High
Congenital Anomalies 6 84.08 Quite High
Cv General 4 Under Development 3 81.76 Quite High
Urological Neuroanatomy 3 68.96 Quite High
Atherosclerosis 8 63.64 Quite High
Disease 11 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S genotype in the HO-1 gene promoter may increase the induction of HO-1 by reactive oxygen species in patients with low HDL-C concentrations.
Spec (may) Positive_regulation (increase) of Positive_regulation (induction) of HO-1 associated with disorder of lipid metabolism
1) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.20 Pain Relevance 0.04
Neither was there any evidence of an induction of HO-1 protein or increased GST activity post wood smoke, table 3.
Positive_regulation (increased) of Positive_regulation (induction) of HO-1
2) Confidence 0.31 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.21 Pain Relevance 0
leads to an induction of heme oxygenase 1 (HO-1) in a dose-dependent manner in
Positive_regulation (leads) of Positive_regulation (induction) of HO-1
3) Confidence 0.19 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809332 Disease Relevance 0.29 Pain Relevance 0
leads to an induction of heme oxygenase 1 (HO-1) in a dose-dependent manner in
Positive_regulation (induction) of Positive_regulation (induction) of oxygenase 1
4) Confidence 0.12 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809332 Disease Relevance 0.28 Pain Relevance 0

General Comments

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