INT29332

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Context Info
Confidence 0.06
First Reported 1986
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.21
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal 1
medulla 1
motor neurons 1
GiV 1
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.98 Very High Very High Very High
Calcitonin gene-related peptide 10 99.64 Very High Very High Very High
fortral 15 99.34 Very High Very High Very High
medulla 4 99.20 Very High Very High Very High
narcan 4 97.68 Very High Very High Very High
backache 134 94.60 High High
Opioid 6 92.24 High High
Pain 178 89.24 High High
opiate 3 86.60 High High
antagonist 2 79.24 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 138 94.60 High High
Pain 180 89.24 High High
Muscle Rigidity 4 87.88 High High
Dystonia 2 63.96 Quite High
Sleep Disorders 6 48.52 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reanalysis omitting the outliers produced SRMs of more comparable magnitude to the rest of the disability measures.
Gene_expression (produced) of SRMs
1) Confidence 0.06 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1635558 Disease Relevance 0.28 Pain Relevance 0.28
OX-A microinjections into GiV sites were less effective in muscle tone facilitation, although these sites produced a muscle tone increase during electrical stimulation.
Gene_expression (produced) of sites in GiV
2) Confidence 0.05 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11976385 Disease Relevance 0.17 Pain Relevance 0.14
In contrast, OX-A microinjections into the gigantocellular nucleus (Gi) sites and dorsal paragigantocellular nucleus (DPGi) sites, previously identified by electrical stimulation as inhibitory points, produced bilateral hindlimb muscle atonia.
Gene_expression (produced) of sites in dorsal
3) Confidence 0.05 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11976385 Disease Relevance 0.15 Pain Relevance 0.15
Lower change scores and SRMs were found for SeS patients.
Gene_expression (found) of SRMs
4) Confidence 0.05 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1635558 Disease Relevance 0.54 Pain Relevance 0.54
Some of the in vivo effects of (+)-pentazocine appear to involve other binding sites that are not detected under the conditions normally used in in vitro assays.
Neg (not) Gene_expression (detected) of sites associated with fortral
5) Confidence 0.04 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8773444 Disease Relevance 0.06 Pain Relevance 1.14
This is consistent with the high and low affinity sites representing the mu 1 and mu 2 sites respectively.
Gene_expression (representing) of sites
6) Confidence 0.04 Published 1986 Journal J. Recept. Res. Section Abstract Doc Link 3012081 Disease Relevance 0 Pain Relevance 0.32
CGRP receptor binding sites (RB) are found in many of the sites where IR axons terminate and in some cases, e.g. motor neurons, which express intraneuronal IR.
Gene_expression (found) of sites in motor neurons associated with calcitonin gene-related peptide
7) Confidence 0.02 Published 1988 Journal Brain Res. Section Abstract Doc Link 2848610 Disease Relevance 0 Pain Relevance 0.37
In the adrenal, opioid receptor sites were found exclusively in the medulla and varied with species.
Gene_expression (found) of sites in medulla associated with medulla and opioid receptor
8) Confidence 0.02 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828979 Disease Relevance 0 Pain Relevance 0.33

General Comments

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