INT293346

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) cytoskeleton (JAK3) cytoplasm (JAK3)
Anatomy Link Frequency
T cells 1
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 19 92.40 High High
corticosteroid 37 55.64 Quite High
Bioavailability 6 44.36 Quite Low
Inflammation 10 16.92 Low Low
Leflunomide 1 15.00 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Combined Immunodeficiency 1 99.76 Very High Very High Very High
Anaemia 4 64.88 Quite High
Thrombocytopenia 4 62.96 Quite High
Renal Failure 11 55.28 Quite High
Neointima 1 34.48 Quite Low
Cytomegalovirus Infection 8 30.00 Quite Low
INFLAMMATION 10 16.92 Low Low
Hepatitis C Virus Infection 52 5.00 Very Low Very Low Very Low
Recurrence 23 5.00 Very Low Very Low Very Low
Nephrotoxicity 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potential for IS by JAK3 inhibitors was discovered serendipitously by the observation gamma-chain mutations of JAK3 were associated with severe combined immunodeficiency in humans, a condition associated with non functional B cells and an absence of T cells and natural killer (NK) cells.
JAK3 Binding (associated) of in T cells associated with severe combined immunodeficiency
1) Confidence 0.12 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.34 Pain Relevance 0.26

General Comments

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