INT293348

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IL15) aging (IL15) Golgi apparatus (IL15)
cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)
Anatomy Link Frequency
T cell 4
IL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 74 5.00 Very Low Very Low Very Low
cytokine 38 5.00 Very Low Very Low Very Low
fibrosis 20 5.00 Very Low Very Low Very Low
Inflammation 20 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 60.40 Quite High
Hypoxia 2 43.28 Quite Low
Organ Transplantation 10 18.80 Low Low
Autoimmune Disease 2 8.40 Low Low
Biliary Cancer 2 7.20 Low Low
Hepatitis C Virus Infection 104 5.00 Very Low Very Low Very Low
Recurrence 46 5.00 Very Low Very Low Very Low
Nephrotoxicity 26 5.00 Very Low Very Low Very Low
Renal Failure 22 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunosuppressive activity of sirolimus activity is primarily related to blockade of IL-2 and IL-15 induction of B and T cell proliferation via inhibition of p70S6 kinase through high affinity binding to FKBP and prevents progression of the cell cycle from the G1 to S phase.
Negative_regulation (inhibition) of Positive_regulation (induction) of IL-15 in T cell
1) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.06 Pain Relevance 0
The immunosuppressive activity of sirolimus activity is primarily related to blockade of IL-2 and IL-15 induction of B and T cell proliferation via inhibition of p70S6 kinase through high affinity binding to FKBP and prevents progression of the cell cycle from the G1 to S phase.
Negative_regulation (blockade) of Positive_regulation (induction) of IL-15 in T cell
2) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.06 Pain Relevance 0

General Comments

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