INT293351

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.22

endosome (IL15) aging (IL15) Golgi apparatus (IL15) cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)

Anatomy Link Frequency NK cells 2 IL15 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 19 88.88 corticosteroid 37 45.96 Bioavailability 6 34.68 Inflammation 10 7.24 Leflunomide 1 5.32 fibrosis 10 5.00 Paracetamol 3 5.00 Antihistamine 2 5.00 agonist 2 5.00 tolerance 2 5.00

Disease Link Frequency Relevance Heat Severe Combined Immunodeficiency 1 92.64 Anaemia 4 86.24 Thrombocytopenia 4 84.32 Renal Failure 11 76.64 Neointima 1 24.80 Cytomegalovirus Infection 8 20.32 INFLAMMATION 10 7.24 Hepatitis C Virus Infection 52 5.00 Recurrence 23 5.00 Nephrotoxicity 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Firstly, loss of NK cells and down regulation of IL-15 transmission may lad to impaired innate immunity and memory.

Negative_regulation (loss) of Regulation (regulation) of IL-15 in NK cells

1) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.34 Pain Relevance 0.22

General Comments

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