INT293368

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppia) protein folding (Ppia) cytosol (Ppia)
signal transduction (CSH1) extracellular region (CSH1) nucleus (Ppia)
Anatomy Link Frequency
T cell 1
CSH1 (Homo sapiens)
Ppia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 38 50.48 Quite High
corticosteroid 74 25.04 Quite Low
fibrosis 20 20.08 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 10 72.04 Quite High
Autoimmune Disease 2 55.48 Quite High
Fungal Infection 4 48.00 Quite Low
Toxicity 2 42.48 Quite Low
Disease 16 20.64 Low Low
Fibrosis 16 20.08 Low Low
Hepatitis C Virus Infection 104 17.28 Low Low
Recurrence 46 5.00 Very Low Very Low Very Low
Nephrotoxicity 26 5.00 Very Low Very Low Very Low
Renal Failure 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Csa and tacrolimus (which inhibit the phosphatase calcineurin after binding to heir respective immunophilins FKBP and cyclophilin, respectively) inhibit early events in T cell activation particularly the expression of IL-2 in the G0-G1 stage of the cell cycle.
Csa Binding (binding) of cyclophilin in T cell
1) Confidence 0.00 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.12 Pain Relevance 0
Csa and tacrolimus are calcineurin inhibitors that bind to their specific immunophilins, cyclophilin and FK binding protein, respectively, before the drug-receptor complex binds to and inhibits calcineurin, a calcium-dependent phosphatase.
Csa Binding (bind) of cyclophilin
2) Confidence 0.00 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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