INT2934

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Context Info
Confidence 0.50
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 1.42
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
neurons 1
intestine 1
Fbxo23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 13 100.00 Very High Very High Very High
Pain 2 99.76 Very High Very High Very High
Neurotransmitter 1 99.68 Very High Very High Very High
anesthesia 1 98.68 Very High Very High Very High
GABAergic 1 98.44 Very High Very High Very High
gABA 74 98.00 Very High Very High Very High
Morphine 4 97.72 Very High Very High Very High
cocaine 4 96.84 Very High Very High Very High
Nucleus accumbens 5 96.16 Very High Very High Very High
agonist 24 94.32 High High
Disease Link Frequency Relevance Heat
Stress 5 99.90 Very High Very High Very High
Poisoning 2 97.52 Very High Very High Very High
Coma 11 96.92 Very High Very High Very High
Pain 1 91.12 High High
Toxicity 7 81.96 Quite High
Unconsciousness 8 79.32 Quite High
Emergencies 2 77.20 Quite High
Targeted Disruption 1 76.72 Quite High
Overdose 49 75.96 Quite High
Death 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While GHB produces euphoria in low doses, small overdosing can result in severe poisoning with coma.
Gene_expression (produces) of GHB associated with coma and poisoning
1) Confidence 0.50 Published 2000 Journal Praxis Section Abstract Doc Link 11021186 Disease Relevance 0.65 Pain Relevance 0.23
GABAergic and glutamatergic synaptic potentials of medium spiny neurons, however, were reduced by baclofen but not GHB.
Neg (not) Gene_expression (reduced) of GHB in neurons associated with gabaergic
2) Confidence 0.47 Published 2009 Journal Neuroscience Section Abstract Doc Link 19446011 Disease Relevance 0.08 Pain Relevance 0.55
[Hepatic energy metabolism disorders in emotionally-painful stress and prevention of these disorders with sodium gamma-hydroxybutyrate].
Gene_expression (prevention) of gamma-hydroxybutyrate associated with stress and pain
3) Confidence 0.44 Published 1978 Journal Vopr. Med. Khim. Section Title Doc Link 569922 Disease Relevance 0.53 Pain Relevance 0.19
The putative GHB receptor antagonist (2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene ethanoic acid (NCS-382) produced 70% GHB-appropriate responding.
Gene_expression (produced) of GHB associated with antagonist
4) Confidence 0.44 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718595 Disease Relevance 0 Pain Relevance 0.85
The putative GHB receptor antagonist (2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene ethanoic acid (NCS-382) produced 70% GHB-appropriate responding.
Gene_expression (produced) of GHB associated with antagonist
5) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718595 Disease Relevance 0 Pain Relevance 0.82
In pigeons trained to discriminate 100 mg/kg GHB from saline, GHB and its precursors gamma-butyrolactone and 1,4-butanediol produced 80 to 100% GHB-appropriate responding, whereas other compounds such as morphine, naltrexone, cocaine, and haloperidol produced no more than 34%.
Gene_expression (produced) of GHB associated with cocaine and morphine
6) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718595 Disease Relevance 0 Pain Relevance 0.61
In pigeons trained to discriminate 100 mg/kg GHB from saline, GHB and its precursors gamma-butyrolactone and 1,4-butanediol produced 80 to 100% GHB-appropriate responding, whereas other compounds such as morphine, naltrexone, cocaine, and haloperidol produced no more than 34%.
Gene_expression (produced) of GHB associated with cocaine and morphine
7) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718595 Disease Relevance 0 Pain Relevance 0.60
Physostigmine was administered intravenously to 25 patients, anaesthetised with sodium gamma-hydroxybutyrate (GHB), and their emergence from anesthesia was studied.
Gene_expression (anaesthetised) of gamma-hydroxybutyrate associated with anesthesia
8) Confidence 0.10 Published 1976 Journal Anaesth Intensive Care Section Abstract Doc Link 984396 Disease Relevance 0 Pain Relevance 0.10
Furthermore, GHB uptake was inhibited by known MCT inhibitors including lactate and pyruvate, suggesting that GHB is a substrate for MCTs expressed at the blood–brain barrier (5).


Gene_expression (expressed) of GHB in blood
9) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
In rat MCT1-transfected MDA-MB231 cells, GHB uptake was inhibited by phloretin, CHC and d-lactate (12).
Gene_expression (uptake) of GHB
10) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Additionally, GHB uptake was inhibited by pCMB indicating that MCT2 may not be an important transporter in GHB uptake (11).
Gene_expression (uptake) of GHB
11) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
All flavonoid aglycones that were evaluated inhibited GHB uptake in MCT1-transfected cells, with luteolin, morin, and phloretin resulting in the greatest reduction in GHB uptake (IC50 values of 0.41, 6.21 and 2.57 ?
Gene_expression (uptake) of GHB
12) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.16 Pain Relevance 0.04
While GHB represents the best studied drug substrate of MCTs, a number of other drugs have been demonstrated to be MCT substrates or inhibitors in various in vitro systems.
Gene_expression (represents) of GHB
13) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
These results suggest that GHB’s absorption is mediated, at least in part, by MCTs in the human intestine.
Gene_expression (absorption) of GHB in intestine
14) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.03
Additionally, GHB uptake was inhibited by pCMB indicating that MCT2 may not be an important transporter in GHB uptake (11).
Gene_expression (uptake) of GHB
15) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0

General Comments

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