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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL8, VEGFA) extracellular region (IL8, VEGFA) signal transduction (IL8)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) intracellular (IL8)
Anatomy Link Frequency
osteoclast 1
IL8 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 98.24 Very High Very High Very High
Inflammation 1 93.52 High High
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 66 100.00 Very High Very High Very High
Metastasis 26 99.68 Very High Very High Very High
INFLAMMATION 1 93.52 High High
Osteolysis 2 87.52 High High
Osteoporosis 6 85.28 High High
Breast Cancer 24 82.32 Quite High
Hypercalcemia 4 68.32 Quite High
Adhesions 9 63.00 Quite High
Death 1 13.60 Low Low
Advanced Or Metastatic Breast Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While VEGF, PTHrP, and IL-11, all of which are critical regulators of tumor angiogenesis [26], [38] and osteoclast resorption [2], [11]–[13], [36], were not affected by the presence of HA, IL-8 secretion increased under these conditions.
IL-8 Neg (not) Regulation (affected) of VEGF in osteoclast associated with cancer
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 1.18 Pain Relevance 0.10

General Comments

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