INT293409

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.18 Pain Relevance 0.10

extracellular space (IL8, VEGFA) extracellular region (IL8, VEGFA) signal transduction (IL8) growth (VEGFA) proteinaceous extracellular matrix (VEGFA) intracellular (IL8)

Anatomy Link Frequency osteoclast 1 IL8 (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 3 98.24 Inflammation 1 93.52 Pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 66 100.00 Metastasis 26 99.68 INFLAMMATION 1 93.52 Osteolysis 2 87.52 Osteoporosis 6 85.28 Breast Cancer 24 82.32 Hypercalcemia 4 68.32 Adhesions 9 63.00 Death 1 13.60 Advanced Or Metastatic Breast Cancer 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While VEGF, PTHrP, and IL-11, all of which are critical regulators of tumor angiogenesis [26], [38] and osteoclast resorption [2], [11]–[13], [36], were not affected by the presence of HA, IL-8 secretion increased under these conditions.

IL-8 Neg (not) Regulation (affected) of VEGF in osteoclast associated with cancer

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 1.18 Pain Relevance 0.10

General Comments

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