INT293415

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.09

signal transduction (HRAS, IL8) Golgi apparatus (HRAS) intracellular (IL8) GTPase activity (HRAS) cytoplasm (HRAS) cytosol (HRAS)

HRAS (Homo sapiens) IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 92.48 cytokine 3 79.52 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 6 96.60 Cancer 66 95.68 INFLAMMATION 1 92.48 Metastasis 26 80.96 Osteolysis 2 68.80 Breast Cancer 24 63.60 Hypercalcemia 4 49.60 Adhesions 9 44.28 Advanced Or Metastatic Breast Cancer 5 5.00 Ehlers-danlos Syndrome 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data support this concept and additionally suggest that HA increases the pro-osteolytic secretion of IL-8 independent of TGF?.

HA Positive_regulation (increases) of Localization (secretion) of IL-8

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

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