INT293419

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 112 98.44 Very High Very High Very High
Breast Cancer 30 88.80 High High
Adhesions 11 58.16 Quite High
Metastasis 49 57.88 Quite High
Osteolysis 5 57.36 Quite High
Advanced Or Metastatic Breast Cancer 6 50.00 Quite Low
Bone Cancer 8 21.40 Low Low
Hypercalcemia 9 19.80 Low Low
Osteoporosis 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have shown that tumor cells respond to 2D substrates with rigidities comparable to that of bone by increasing expression and secretion of the osteolytic factor PTHrP.
Positive_regulation (increasing) of Localization (secretion) of PTHrP associated with cancer
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.61 Pain Relevance 0
VEGF, IL-11, and IL-8 ELISAs (R&D) were performed on these samples according to manufacturer's instructions, while PTHrP secretion was measured using a two-site immunoradiometric assay (Beckman Coulter).
Positive_regulation (measured) of Localization (secretion) of PTHrP
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.42 Pain Relevance 0

General Comments

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